adenosine 5 monophosphate Raw Materials powder supplier

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Adenosine 5'-monophosphate Usage and Function.

5'-Adenylic acid is a chemical compound with the molecular formula C10H14N5O7P that has a variety of biological activities. It can trigger a cascade reaction by stimulating Gαs protein-coupled adenylate cyclase, leading to the intracellular aggregation of the second messenger cyclic Adenosine monophosphate (cAMP).

Additionally, 5'-adenosine can be used as a substrate that is catalyzed by deoxyadenylase to produce deoxyadenosine acid. 5'-adenosine acid is present in liver, kidney, and microorganisms and is highly stable.

In addition, 5'-adenylic acid has antitumor effects, inhibiting the growth and proliferation of tumor cells.

Uses of Adenosine 5'-monophosphate.

A naturally occurring nucleotide that facilitates the binding of APS reductase inhibitors and activates adenosine receptor agonists.
It can be used as intermediates in the production of nucleotide drugs, food additives and biochemical products, and is used in the production of antiviral drugs, synthetic energy drugs and cardiovascular drugs, such as adenosine adenosine, ATP, adenosine 3'-5'-cyclohexylphosphate and so on.
It can be used as the intermediates of nucleic acid drugs, health food and biochemical reagents, and used in the manufacture of adenosine triphosphate (ATP), cyclic adenosine monophosphate (cAMP) and other biochemical drugs.
Clinically used in disseminated sclerosis, porphyria, pruritus, liver disease, varicose ulcer complications. Complex eye drops based on adenosine acid components can be used for eyestrain, central retinitis and corneal opacities and herpes and other corneal surface disorders. Intramuscular injection is seen as local erythema, generalized vasodilatation, flushing of the face, dizziness, dyspnea, palpitations.

Product method of Bulk Adenosine 5'-monophosphate Powder.

Mycelium as raw material extraction, precipitation of mycelium with 3 times the amount of water, processing of industrial alkali, so that the concentration of 0.25% (g/100ml), stirring for 1h, add 20% sulfuric acid pH = 7, filtration, filtrate with 20% sulfuric acid pH = 2.5, centrifugation, to get the nucleic acid mud.

Mycelium [sodium hydroxide] → [1h] extract [20% sulfuric acid] → [pH7, filtration] filtrate [20% sulfuric acid] → [pH2.5, centrifugation] Nucleic acid mud solubilization, enzymolysis, adsorption, and elution of the nucleic acid mud was prepared into a 1% solution, adjusted with 10% ammonia to pH=6-6.2, heated at 90 ℃ for 20min, cooled, centrifuged, and the supernatant warmed up to 65-70 ℃ after adding One-third of the phosphodiesterase solution, 2h after warming to 90 ℃, 10min after cooling to room temperature, add 20% sulfuric acid solution to adjust pH = 2.5-3, filtration, filtrate with 10% ammonia to adjust pH = 7.2-7.5, and add 0.3% (3g / L) diatomaceous earth to aid filtration, the filtrate on the anion-exchange resin column 717 type, with 0.05mol / L of sulfuric acid elution.

Nucleic acid sludge [ammonia] → [pH 6-6.2,90℃,20min] clear solution [phosphodiesterase] → [65-70℃,2h] hydrolysate [717 resin] → adsorbate [sulfuric acid] → eluent [732 resin] → AMP, CMP, GMP mixed adsorbent adsorption, elution, crystallization eluent adsorbed by a 732-type cation exchange counting resin column, eluted with pH1.5 Elution with distilled water, when the eluate with bromine water has red color, start to collect, concentrate the eluate to 80-90mg/ml under reduced pressure, add diatomaceous earth, stirring for 30min, filtration, the filtrate is adjusted with 6 mol/L hydrochloric acid to pH=2.5, stirring and cooling to make full crystallization, filtration, anhydrous ethanol washed for 3 times, vacuum drying at 60 ℃, to get the finished product of AMP.

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