Notoginsenoside Raw Materials Notoginsenoside powder

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Notoginsenoside Powder Usage and Synthesis.

Panax notoginseng saponin R1 is the main active monomer of Panax notoginseng total saponin, which is mainly found in the dried roots and rhizomes of Panax notoginseng. It has anti-inflammatory, anti-cancer, microcirculation improvement, and prevention of ischemia-reperfusion injury effects.

The substance can be detected by high performance liquid chromatography (HPLC) and liquid-mass spectrometry (LC-MS) techniques. The extraction process of Panax ginseng saponin R1 includes weighing Panax ginseng powder precisely, adding methanol, leaving it overnight, then heating it, weighing it again, replenishing the lost weight with methanol, filtering it, and taking the renewed filtrate to obtain.

Uses of Notoginsenoside.

1、Improve microcirculation and protect cardiovascular effects:In the 1990s, there have been studies on the mechanism of NTRl to improve cardiovascular disease.

Studies have claimed that NTRl has the effect of promoting the synthesis of fibrinolytic system in a variety of vascular-related cells; its mechanism of action may be through the inhibition of endothelial cell E-selectin and neutral leukocyte CD18 protein expression.

Another study showed that NTRl can inhibit TNF_a-induced elevated levels of fibronectin and cell migration in venous endothelial cells at the cellular level by inhibiting ERK activation and NADPH oxidase-mediated ROS generation.

2, anti-inflammatory effect:Tail vein injection of NTRl can reduce lipopolysaccharide (LPS)-induced death in mice.NTRl can also inhibit the LPS-induced elevation of TNF-a in human whole blood cell culture.

Recent studies have found that NTRl inhibits inflammatory factors of the NF-κB pathway and attenuates myocardial inflammatory response and apoptosis in a mouse model of lipopolysaccharide-induced cardiac dysfunction. This effect may be through the upregulation of estrogen receptor a (ERa) and PI3K/Akt pathway.

3, other effects:NTR1 also has a certain anti-tumor and antioxidant effects.

Preparation of Notoginsenoside.

Produt Method of Notoginsenoside.

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