High Purity AMPK O-304 Powder CAS 1261289-04-6 Supplier

CAS: 1261289-04-6

MW:380.25

Formula:C16H11Cl2N3O2S

Target:AMPK

Purity:≥98%

Model Number:ASRN-O-304 powder

Specification: 99% min O-304 powder

Sample:O-304 powder Avaliable

Keywords:O-304 powder

Brand: Ausreson

Appearance:White powder

Storage conditions: Powder stored at -25~-15℃, valid for 3 years; 

dissolved in solvent, stored at -85~-65℃, valid for 2 years

Test Method: HPLC

What is O-304?

CAS 1261289-04-6 - cGMP O-304 Powder (Lot-Traced) is a first-in-class, orally available pan-AMPK activator that increases AMPK activity by inhibiting the dephosphorylation of pAMPK. O-304 in 2024 IND-enabling studies has great potential in the treatment of type 2 diabetes and related cardiovascular complications.

Pharmacokinetics.

Research Applications

Primary Indications:

Age-related NAD+ decline

Metabolic syndrome (insulin resistance, obesity)

Experimental Models:

In vivo: High-fat diet mice (reduced adiposity + improved glucose tolerance)

In vitro: Human primary hepatocytes (↑ mitochondrial respiration)

Mechanism of Action

Primary Target: CD38 (Cluster of Differentiation 38)

Inhibits NAD+-glycohydrolase activity → ↑ Intracellular NAD+ levels

Secondary Effects:

AMPK activation (mimics calorie restriction) O-304 raw material suppliers in China.

SIRT1/PGC-1α pathway stimulation High-Purity O-304 Powder

Product Safety and Compliance Details

Safe use

As the Food and Drug Administration (FDA) advises, dietary supplements can support your overall health but may also have powerful effects on the body. It’s important to read labels carefully, exercise caution, and consult your healthcare professional before taking any supplement. Side effects are more likely if supplements are taken in high doses, as substitutes for prescribed medications, or in combination with multiple supplements. If you experience severe side effects, discontinue use immediately and seek medical attention.

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