nmn Nicotinamide Mononucleotide Raw Materials powder supplier

CAS:1094-61-7

MF:C11H15N2O8P

MW:334.22

EINECS:214-136-5

OEM:Customized logo is welcome, Packing as your requirement. offering private label

Specification​: 99% min Nicotinamide Mononucleotide powder

Sample:Nicotinamide Mononucleotide powder Avaliable

Packaging:1kg/bag, 25kg/drum

Brand: Ausreson

MOQ:1KG

Appearance: White powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

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Nicotinamide Mononucleotide powder Usage and Synthesis.

Beta-nicotinamide mononucleotide is the precursor substance of NAD+, a cofactor of longevity proteins in the human body.

NAD+ is an important coenzyme of the tricarboxylic acid cycle, which promotes the metabolism of sugars, fats, and amino acids, and participates in the synthesis of energy; NAD+ is also the only substrate for the coenzyme I depletion enzymes (the only substrate for the DNA repair enzyme PARP, the only substrate for the longevity proteins Sirtuins, and the only substrate for the cyclic ADP-ribose synthetase CD38/157).buy nicotinamide mononucleotide nmn supplement online

NAD+ is involved in all aspects of human metabolism and is a key coenzyme. Without NAD+, metabolism will not work, and the elderly lack NAD+, so all kinds of big and small problems come, and by supplementing NAD+ additionally, it can be a comprehensive anti-aging.nicotinamide mononucleotide nmn Amazon

Preclinical studies have shown a variety of pharmacological activities of NMN in cardiac and cerebral ischemia, Alzheimer's disease, dietary and age-induced type 2 diabetes and obesity, NMN as a precursor drug for NAD+, mainly synthesized in the body to play a pharmacological role in the synthesis of NAD+, all of which are related to the lack of NAD+.

Uses and functions of Nicotinamide Mononucleotide powder.

In mammals, β-nicotinamide mononucleotide is produced from nicotinamide (Nam) catalyzed by Nampt (a protease in vivo), and subsequently nicotinamide mononucleotide is catalyzed by nicotinamide mononucleotide adenylyltransferase to produce NAD+. Nicotinamide mononucleotides are a direct way to replenish NAD+.

It is by significantly enhancing the ability to repair intracellular DNA damage that nicotinamide mononucleotide ultimately achieves the reversal of aging. Nicotinamide mononucleotide is converted into nicotinamide adenine dinucleotide (NAD), which is essential for energy metabolism in the body.

In mouse tests, it has been shown that nicotinamide mononucleotide can activate a gene called acetylase in the body, thus exerting such effects as prolonging life and treating diabetes, etc. NAD is a substance that the human body can originally produce, and studies have confirmed that the amount of NAD in the body decreases with age.

Efficacy and Application of nicotinamide mononucleotide supplement

β-Nicotinamide mononucleotide (NMN) has shown effective therapeutic effects in animal models of diseases such as diabetes, cerebral ischemia, and Alzheimer's disease, mainly by stimulating the synthesis of NAD+. Compared with direct NAD+ administration, NMN administration is easier to penetrate the cell membrane, not only better exerting its pharmacological activity, but also avoiding side effects such as anxiety and insomnia caused by high-dose NAD+ intake. In addition, NMN can also effectively treat cerebral hemorrhage, reduce fat and lose weight, repair DNA damage, improve dark vision and retinal function, improve mitochondrial energy status, and promote neurovascular regeneration.

Synthesis of nicotinamide mononucleotide nmn

Currently, exogenous NMN production methods primarily fall into two categories: chemical synthesis and biological methods. The former, which was studied earlier, primarily utilizes nicotinamide and ribose as raw materials through various synthetic steps. However, its complex technical route, harsh reaction conditions, high production costs, and low product yield and purity significantly limit its application and widespread adoption. Compared to chemical synthesis, biological methods offer advantages such as a simpler technical route, convenient operation, environmental friendliness, and low production costs.

Chemical Methods

① Bromoacetylribose Method

The bromoacetylribose method has a four-step reaction process.

• First, the hydroxyl-protected ribose undergoes bromination or chlorination.
• Second, it undergoes a condensation reaction with nicotinamide in a solvent to produce a nucleoside.
• Next, the protecting group is removed by ammonia deprotection, followed by reaction with phosphorus oxychloride in trimethyl phosphate or triethyl phosphate. Finally, hydrolysis produces nicotinamide mononucleotide.

② TMSOTF-catalyzed condensation method: Nicotinamide (NAM) undergoes a condensation reaction with the hydroxyl-protected ribose and the catalyst TMSOTF to produce a mixture of α- and β-NMN. β-NMN can be obtained by separation on an activated carbon column.

• This method offers strong stereoselectivity, short reaction time, simple separation, and high yield. However, the disadvantage is that the excess silanization reagent must be distilled off after the silylation reaction, which requires relatively harsh conditions. AMP Acid Hydrolysis Catalytic Method
• This method uses adenosine monophosphate (AMP) as the starting material. It is hydrolyzed to ribose phosphate under acidic conditions, which then reacts with ammonia/ethylene glycol to form unstable ribosylamine phosphate. Nicotinamide then condenses with 1-chloro-2,4-dinitrobenzene to form NDC (dinitrochlorobenzene condensation). Finally, NDC reacts with ribosylamine phosphate to produce NMN.
• The disadvantages of this method include low stereoselectivity, unstable and easily decomposed intermediates, high raw material toxicity, and low yield.