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Glimepiride can improve blood glucose control in type 2 diabetes patients, and its efficacy is similar to that of other second-generation sulfonylureas. However, glimepiride only needs to be taken once a day and is well tolerated. Glimepiride is a convenient and safe alternative sulfonylurea for type 2 diabetes patients who simply use diet and exercise to treat poor blood glucose control. In type 2 diabetes patients with secondary failure of sulfonylureas, glimepiide combined with insulin can reduce the dose of exogenous insulin. At present, studies suggest that glimepiride is well tolerated, but more information is needed on the use of glimepiride in combination with other hypoglycemic agents. Glimepiride only needs to be taken once at breakfast, which is convenient and easy, and the efficacy is certain, the interaction between drugs is less, and the side effects are relatively mild, so the application prospect is optimistic.
Uses of Glimepiride.
Product Method of Bulk Glimepiride Powder.
3-ethyl-2, 5-dihydro-4-methyl-2-oxygen-1H-pyrrole reacts with phenyl ethyl isocyanate, then chlorosulfonates with chlorosulfonic acid, amolysis to sulfonamide, and finally condensation with isocyanate p-methylcyclohexyl ester, resulting in a product. Or the product of chlorosulfonation first reacts with methyl carbamate, and then condensates with p-methylcyclohexylamine, the product can also be obtained.
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