Anti-tumor Carboplatin raw materials powder

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Carboplatin Usage and Synthesis.

Carboplatin is a platinum-based anticancer drug that damages DNA by forming in-chain conjugations with neighboring guanine residues. The anti-tumor effect of these drugs is achieved through the activity of DNA mismatch repair loss (MMR vaccine) and induced programmed cell death.

The role and use of the second generation of platinum anticancer drugs are basically the same as that of cisplatin. It is more active than cisplatin for some tumors and stronger than cisplatin as a radiosensitizer under hypoxia conditions. It is mainly used for ovarian cancer, testicular cancer, small cell lung cancer and head and neck cancer.

Uses of Carboplatin.

Carboplatin acts directly on DNA, destroying DNA molecules by causing cross-links between and within DNA chains, preventing its helical unwinding, interfering with DNA synthesis, thereby producing cytotoxic effects and inhibiting tumor growth. It is mainly suitable for small cell lung cancer, ovarian cancer, testicular cancer, head and neck squamous cell carcinoma, etc. It can also be used to treat various solid tumors such as non-small cell lung cancer, bladder cancer, cervical cancer, pleural mesothelioma, liver cancer, etc. It can also be used as a drug for radio-enhanced therapy.

Product Method of Bulk Carboplatin.

Potassium chloroplatinate reacts with hydrazine hydrochloride and potassium iodide to obtain cisiodoamine platin, which can be purified by recrystallization of a mixture of dimethylformamide and ethanol. Cisiodoplatine was added to the water, silver sulfate was slowly added, and the reaction was 2 ~ 3h at 20 ~ 25℃. Filter the insoluble matter, slowly add barium 1, 1-cyclobutane dicarboxylate (obtained from the reaction of 1, 1-cyclobutane dicarboxylate and barium hydroxide) to the filtrate, react at room temperature for 3 ~ 4h, stand for more than 12h, filter, and steam the filtrate. The resulting solids were washed with water and 95% ethanol, respectively. Drying at about 60℃, carboplatin is obtained. The yield is 87.5%.

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