Pharmaceutical Baclofen raw material Powder

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Baclofen powder Usage and Synthesis.

Gamma-aminobutyric acid (GABA) is very high in the human central nervous system brain and spinal cord, which is more than 1000 times higher than the brain monoamines such as catecholamine, norepinephrine, dopamine, etc., which is the highest in the substantia nigra and the pallida pallida, and about 20% to 40% of the synapses in the brain are GABA as a transmitter. GABA is a major inhibitory transmitter in the brain and spinal cord of the central nervous system, but it cannot cross the blood-brain barrier.

GABA becomes baclofen by attaching para-chlorophenyl to carbon atoms, changing from a hydrophilic substance to a lipophilic one, thus allowing it to cross the blood-brain barrier. The main function of this product is to stimulate GABA receptors, inhibit the release of excitatory amino acids such as aspartic acid and glutamic acid through synapses, and cause K+ and Ga+2 ions to outflow in neurons, resulting in hyperpolarization, reduce the transmission of monosynaptic and polysynaptic reflex, promote the normal activity of interneurons, and reduce the activity of motor neurons. It can relieve the spasm of skeletal muscle caused by pyramidal tract damage, reduce muscle tension and promote the recovery of motor function.

Uses of Baclofen.

Baclofen is a spasmolytic. It inhibits both monosynaptic and polysynaptic spinal cord transmission by activating GABA-receptors and inhibiting the release of excitatory amino acids glutamate and aspartate. Therefore, it can reduce the increase of limb muscle tone caused by myelopathy, multiple sclerosis and spinal cord injury. For muscle spasms caused by diseases or injuries of the spinal cord and brain.

Pharmacological action of Bulk Baclofen powder.

Product Methods of Baclofen.

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