Veterinary Medicine Dimetridazole 1,2-Dimethyl-5-nitroimidazole Powder CAS 551-92-8 Raw Materials

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Dimetridazole Powder Usage and Synthesis.

Dimetridazole Powder is also known as Dimetridazole, 1,2-Dimethyl-5-nitroimidazole Powder is a kind of white or yellowish powder, odorless, bitter taste, gradually become black when exposed to light, easily soluble in chloroform and ethanol, slightly soluble in water or ether.

Dimetridazole Raw Materials are mainly used as Dimetridazole Raw Materials is mainly used as veterinary antimicrobial agent, which is the first choice for the prevention and treatment of swine dysentery, Dimetridazole Powder can be used as feed additives, which is good for promoting the growth of livestock and poultry, and a small amount of it is used in daily chemicals.

Uses and functions of Dimetridazole Powder.

• It is a growth promoter for livestock and poultry and high efficient, low toxicity broad-spectrum antiprotozoal drug. It can be used in pig feed with dosage of 50-100g/t; it can also be used in chicken feed with dosage of 125-200g/t.
• Usage Dimethenamidazole has a significant inhibitory effect on the protozoa such as Trichomonas, Trichomonas bovis, Colonic Pouch Worm, Flagellate, and bacteria such as Anaerobic filamentous bacillus necrophorum, Clostridium perfringens, Anaerobic staphylococcus, Vibrio intestinalis, and Spiroplasma densiflorum, etc. It is an effective drug for the treatment of blackhead disease of turkey and red diarrhea of swine.

• It can also be used as growth promoter to promote the production of pigs and chickens and improve the feed conversion rate. When used as a feed additive, the product should be premixed with 10-20 times the amount of feed at the time of feed processing, and then evenly mixed with the total amount of feed required.

Pharmacological Effects of Dimetridazole Powder.

1. Alternatively, mix the product with an appropriate amount of carrier and then add it to the feed. When processing compound feeds, pelleting and other operational procedures have no effect on the effectiveness of this product.
2. The product can be mixed into the feed or added into the drinking water for livestock and poultry to drink. Metronidazole is of low toxicity, well tolerated by animals and has no carcinogenic or teratogenic effect.

1. The product is rapidly absorbed in the intestinal tract, distributed in various tissues, and circulated into the intestine and liver through the biliary tract.
2. In the body of livestock, it is excreted after oxidative and reductive metabolism. Residues in the carcass, after 48h or after cooking, the vast majority is destroyed.
3. Decomposition in the soil is also faster, so it will not lead to pollution of the environment. The product is stable and can be stored in a dry place under 37℃ for two years.

Production method of Dimetridazole Powder.

Take glyoxal as the starting material, cyclize with acetaldehyde and ammonia to get 2-methylimidazole (C4H5N2, [693-98-1]). Then nitration, to obtain 2-methyl-5-nitroimidazole (C4H6N3O2Chemicalbook, [696-23-1]. Final methylation with dimethyl sulfate yields methylnitroimidazole. The intermediate 2-methylimidazole can also be obtained by cyclization of ethylenediamine with acetonitrile to obtain 2-methylimidazoline, and then catalytic dehydrogenation with activated nickel.

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