L-proline Raw materials Powder CAS:147-85-3

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L-proline Powder Usage and Synthesis.

L-proline is a non-essential amino acid that is widely found in proteins, especially collagen. In plants, the content of proline increases significantly under adverse conditions (e.g., drought, high temperature, low temperature, salinity, etc.), which suggests that proline plays an important role in plant stress tolerance.

In addition, proline has a wide range of clinical, biomaterial and industrial applications.L-proline and D-proline are two common forms of proline, of which L-proline is the naturally occurring form.L-proline is used as an amino acid analog in clinical medicine for the treatment of a wide range of diseases.L-proline is also commonly used in the preparation of culture media and biochemical research.

Uses of L-proline.

Used in biochemical research and in medicine for malnutrition, protein deficiency, gastrointestinal disorders, scald and postoperative protein supplementation. Amino acid medicine. One of the raw materials for compound amino acid infusion, used for protein supplementation after malnutrition, protein deficiency, severe gastrointestinal disorders, scald and surgery.

Nutritional supplements. Flavor agent, and sugar co-heating amino-carbonyl reaction can generate a special flavor material. It can be used as flavor according to GB2760-86. Used in amino acid injection, compound amino acid infusion, food additives, nutritional supplements and other pharmaceutical raw materials and food additives.

Characteristic of L-proline.

Colorless crystal, odorless, sweet taste; soluble in water (solubility 162.3g/100ml in water at 25°C) and ethanol, insoluble in butanol and ether, yellow when met with hydrated ninhydrin test solution, glacial acetic acid acid acidification shows red; pI6.3, decomposition point 220-222°C; specific optical rotation [α] 20D-85° (0.5-2.0mg/ml, H2O), [α] 20D-60.4° (0.5-2.0 mg/ml, 5 mol/L HCl).

Product Method of Bulk L-proline Powder.

There are two methods of L-proline production.

One is the direct fermentation method, which utilizes glucose and Pseudomonas aeruginosa variant or wild strain of Corynebacterium glutamicum to obtain L-proline by microbial fermentation;

The second is the chemical synthesis method, using glutamic acid as raw material, esterification with anhydrous ethanol catalyzed by sulfuric acid, and adding triethanolamine to free the aminosulfate, to get glutamic acid-δ-ethyl ester.

Then use the metal reducing agent potassium borohydride to reduce glutamic acid-δ-ethyl ester, get the crude proline, and finally its separation and purification can get the crude proline.

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