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As food iron fortifier, the absorption effect is better than inorganic iron. China's regulations can be used in salt and sandwich sugar, the use of 3600 ~ 7200mg / kg; in high iron cereals and their products (daily limit of 50g of such food) for 1000 ~ 1200mg / kg; in dairy products and baby food for 360 ~ 600mg / kg; in cereals and their products for 150 ~ 290mg / kg; in beverages for 60 to 120mg/kg in beverages.
Uses and functions of best Ferric Citrate.
As food iron fortifier, the absorption effect is better than inorganic iron. China's regulations can be used in salt and sandwich sugar, the use of 3600 ~ 7200mg / kg; in high iron cereals and their products (daily limit of 50g of such food) for 1000 ~ 1200mg / kg; in dairy products and baby food for 360 ~ 600mg / kg; in cereals and their products for 150 ~ 290mg / kg; in beverages for 60 to 120mg/kg in beverages.
It is used as food additives, added to biscuits, milk powder and flour, as iron nutrient fortifier, also used as feed additives, iron citrate is also used as medicine, used in blueprint photographic paper and so on.
Preparation of Ferric Citrate.
1, citric acid is added to the iron hydroxide solution, heated to below 60 ℃, evaporated and concentrated to slurry, and obtained by low-temperature drying on a glass plate.
2, add ammonia to iron sulfate solution to produce iron hydroxide precipitation. Filter and wash with water until there is no reaction of sulphuric acid. Add citric acid and heat to below 60℃ with stirring to dissolve all the precipitate, then filter. Concentrate the filtrate into syrupy form by heating below 60℃, coat it into a thin layer on a glass plate, form small leaves, peel it off, slightly warm and dry it.
Mechanism of Action
The therapeutic effects of ferric citrate stem from its unique mechanism of action. After entering the body, ferric iron (Fe³⁺) is absorbed in the gastrointestinal tract via metallotransferase-1, a process that requires reduction to ferrous iron (Fe²⁺) by ferric reductase and cytochrome B reductase.
The absorbed iron undergoes several fates in the body: some is stored by ferritin; some enters the bloodstream via ferrotransferases and is ultimately carried to tissues that require iron.
Regarding phosphorus binding, the iron ions in ferric citrate bind with phosphate in the gastrointestinal tract, forming insoluble ferric phosphate, which is excreted in feces, thereby reducing blood phosphorus concentration.
This mechanism is particularly important for patients with renal insufficiency who cannot excrete phosphorus normally, effectively preventing complications caused by hyperphosphatemia.
It is worth noting that the bioavailability of ferric citrate is approximately 19% of that of ferrous ascorbate, meaning its iron absorption efficiency is relatively low, but this also reduces the risk of side effects from excessive iron intake.
Product Method of Bulk Ferric Citrate Powder.
Ammonia is added to the iron sulphate solution to produce a precipitate of iron hydroxide. Filter and wash with water until there is no sulphuric acid reaction. Citric acid was added and heated to below 60°C with stirring to dissolve all the precipitate, then filtered. Concentrate the filtrate into syrupy by heating below 60 ℃, coat it into a thin layer on a glass plate to form small leaves, peel it off, slightly warm it and dry it to be obtained.
Frequently Asked Questions
What are the main uses of ferric citrate?
Ferric citrate has two main uses: first, as a medication to control blood phosphorus levels in patients with chronic kidney disease and treat iron-deficiency anemia; second, as a nutritional fortifier added to food to supplement iron.
How does ferric citrate work as a medication?
Ferric citrate works through two mechanisms: first, iron ions bind with phosphates in the gastrointestinal tract to form insoluble compounds that are excreted in feces, lowering blood phosphorus; second, it supplements iron, improving iron-deficiency anemia. It is particularly suitable for kidney disease patients who need to address both of these issues simultaneously.
How safe is ferric citrate?
Ferric citrate has passed multiple safety assessments. The US FDA has approved it for the treatment of kidney disease, and the EU has also confirmed its safety in food. Common side effects include gastrointestinal discomfort and changes in stool color, which are usually mild.
What is the difference between ferric citrate and ferrous citrate?
Both are ferric citrate salts, differing mainly in the valence state of the iron ions: ferric citrate contains ferric iron (Fe³⁺), while ferrous citrate contains ferrous iron (Fe²⁺). This leads to differences in their bioavailability, stability, and applications.
What precautions should be taken when using ferric citrate?
When using ferric citrate, blood phosphorus and iron storage levels should be monitored to avoid iron overload; be aware of possible gastrointestinal side effects; interactions with certain medications and foods are possible; therapeutic doses of ferric citrate are not necessary for individuals with normal renal function.
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Поставщик порошка цитрата железа высокой чистоты оптом
Fournisseur de poudre de citrate ferrique de haute pureté en vrac
Lieferant von hochreinem Eisen(III)-citrat-Pulver in Großmengen
Proveedor de polvo de citrato férrico de alta puretidad a granel
Fornecedor de pó de citrato férrico de alta pureza a granel
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