Menadione Raw Materials Menadione Powder

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Product details

Menadione Powder Usage and Synthesis.

Vitamin K3 is white or off-white crystalline powder, agglomerated after moisture absorption, easily soluble in water and hot ethanol, insoluble in ice ethanol, insoluble in benzene and, aqueous solution PH4.7-7. It is stable at room temperature, easily decomposed when exposed to light.

Vitamin K3 is a pro-coagulant, it can be used to treat some bleeding disorders caused by vitamin K deficiency, vitamin K3 is also called naphthoquinone, it can promote the formation of plasminogen, but also has a diuretic effect, can reduce blood pressure, sometimes vitamin K3 is used as a colouring agent or food additives.

Uses and functions of Menadione.

Feed additive raw materials, mainly can promote livestock and poultry liver synthesis of thrombinogen, and promote plasma coagulation factor synthesis in the liver, for hemostatic agent.

Biochemical research, clinical drugs are fat-soluble vitamins, clinical as haemostatic drugs.

First, promote blood coagulation, vitamin K3 can make fibrinogen into fibrin.

Second, involved in energy metabolism, vitamin K3 is an important component of the composition of the cellular respiratory chain is an intermediate product of oxidative phosphorylation in the k body.

Third, increase muscle elasticity, vitamin K3 can promote intestinal peristalsis, stimulate the secretion of the digestive glands, so that the digestive tract function normally.

Adverse reactions of Menadione.

1. Local redness, swelling and pain can be seen.

2. Larger doses may cause haemolytic anaemia, hyperbilirubinaemia and jaundice in neonates and preterm infants. In patients with erythrocyte 6-phosphate dehydrogenase deficiency can induce acute haemolytic anaemia.

3. Hepatic damage can be caused by the use of large doses. Patients with hepatic insufficiency may switch to vitamin K1.

Product Method of Bulk Menadione Powder.

1. Methyl naphthalene is obtained by oxidation with chromic anhydride. Dissolve 2-methylnaphthalene in glacial acetic acid, stirring and cooling to below 40 ℃, slowly add chromic anhydride and an equal amount of water mixture, so that the temperature is maintained at 35-40 ℃.

After addition, hold at 40℃ for 0.5h, raise the temperature to 70℃ and hold for 45min, then raise the temperature to 85℃ and hold for 15min, pour the reactants into a large amount of water, and precipitate 2-methylnaphthalene quinone under constant stirring. Filtering, the filter cake was washed with water repeatedly until the aqueous solution had no acidic flavour, and filtered dry to obtain 2-methylnaphthoquinone. Yield 51%. 2-methylnaphthalene can also be used in sodium dichromate, potassium dichromate oxidation yield is about the same.

2. 2-methyl naphthalene hydroquinone was obtained by cycloaddition of methylbenzoquinone and butadiene, and then oxidised by chromic acid. Methylbenzoquinone was added to glacial acetic acid to dissolve, and butadiene was passed to the desired amount at 20°C or less.

After closed and standing for 20h, heating to make the remaining butadiene escape, continue to heat to about 110 ℃ reflux 3h, and then distillation under reduced pressure to recover glacial acetic acid about 30%.

Then cooled to below 40 ℃, slowly add chromic acid and an equal amount of water mixture, so that the temperature is maintained at 65-70 ℃, add the end, at 70-80 insulation 1h to produce menaquinone.

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