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At present, clindamycin hydrochloride is mainly used clinically for the treatment of infections caused by gram-positive cocci and various anaerobic bacteria, for the treatment of joint, bone marrow, respiratory tract and soft tissue skin infections, as well as tonsillitis, pharyngitis, pneumonia, and for a variety of infections, such as acne, gynecological inflammation, endocarditis, and pustular chest.
Acne vulgaris is a skin disease frequently seen in clinical practice, and the causes of its pathogenesis have been studied, mainly being infected by aerobic and anaerobic bacteria, of which the anaerobic bacteria is Propionibacterium acnes. According to various data, the above pathogenic bacteria are within the range of antibacterial spectrum of clindamycin, and the use of clindamycin gel for the treatment of acne vulgaris can achieve a cure rate of 93.3%; 2% clindamycin hydrochloride cream (oil-in-water type), which can be used for the treatment of vaginitis, with the advantages of good effect, non-irritation, and high concentration of the local drug, can be used for the treatment of bacterial vaginitis.
Clindamycin hydrochloride is easy to dissolve, with high distribution coefficient in the body, less adverse reactions and less influence by daily diet. It can be made into various dosage forms such as tablets, injections, applications, gels, vaginal effervescent tablets and so on.
However, the biological half-life of the drug is short, about 3 hours, so the drug is administered 3-4 times a day. In order to reduce the number of times the drug is administered, maintain the stability of the blood concentration, improve the patient's compliance, and improve the therapeutic effect, there have been reports of slow and controlled release preparations.
Uses and functions of clindamycin hydrochloride.
Clindamycin hydrochloride is a derivative of lincomycin, which is many times more active than lincomycin against Aureus and Pneumococcus.
Clindamycin is a derivative of Zeomicin, which is a semi-synthetic antibiotic obtained by replacing the hydroxyl group at the 7-position of Zeomicin with a chlorine atom.
Antimicrobials. The antibacterial spectrum is similar to that of Zeomicin.
Pharmacological Effects of clindamycin hydrochloride.
Clindamycin is a semi-synthetic antibiotic with a broad antibacterial spectrum and strong antibacterial activity. It has significant antibacterial activity against Gram-positive bacteria and can effectively kill staphylococci, anaerobes, pneumococci and streptococci. It has active effects on pathogenic parasites such as Pneumocystis, Toxoplasma, Plasmodium falciparum, etc., and has little adverse reactions.
Clindamycin products currently used in clinical practice include clindamycin hydrochloride, clindamycin phosphate, and clindamycin palmitate, of which clindamycin phosphate and clindamycin palmitate have no antibacterial activity of their own, and exert antibacterial and antiparasitic effects after being metabolised in vivo to clindamycin.
Clindamycin hydrochloride is a derivative of lincomycin, the antibacterial spectrum of clindamycin hydrochloride is wider than that of lincomycin, and the antibacterial activity is 4-8 times higher than that of lincomycin. It has antibacterial activity against Gram-positive aerobic bacteria, staphylococci, streptococci, and also against mycoplasma, chlamydia and a variety of anaerobic bacteria.
Production Method of Bulk clindamycin hydrochloride Powder.
Clindamycin is a derivative of Zeomicin, a semi-synthetic antibiotic obtained by replacing the hydroxyl group at the 7-position of Zeomicin with a chlorine atom.
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