Pharmaceutical Bulk β-Nicotinamide Mononucleotide Powder

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β-Nicotinamide Mononucleotide Powder Application.

β-nicotinamide mononucleotide is the precursor of NAD+, a cofactor of longevity proteins in the human body.NAD+ is an important coenzyme of the tricarboxylic acid cycle, which promotes the metabolism of sugars, fats and amino acids, and participates in the synthesis of energy; NAD+ is also the only substrate of the coenzyme I depletion enzymes (the only substrate of PARP, a DNA repair enzyme; the only substrate of longevity proteins; the only substrate of the cyclic ADP-ribose synthetases; the only substrate of CD38/157). CD38/157).

NAD+ is involved in all aspects of human metabolism and is a key coenzyme. Without NAD+, metabolism will not work, and the elderly lack NAD+, so all kinds of big and small problems come, and by supplementing NAD+ additionally, it can be a comprehensive anti-aging.

Preclinical studies have shown that NMN has a variety of pharmacological activities in cardiac and cerebral ischaemia, Alzheimer's disease, diet and age-induced type 2 diabetes mellitus and obesity, and that NMN, as a precursor to NAD+, is mainly synthesised in vivo to play a role in the pharmacological effects of NAD+, all of which are associated with the lack of NAD+!

Uses and functions of β-Nicotinamide Mononucleotide.

In mammals, β-nicotinamide mononucleotide is produced from nicotinamide (Nam) catalysed by Nampt (a protease in vivo), and subsequently nicotinamide mononucleotide is catalyzed by nicotinamide mononucleotide adenylyltransferase to produce NAD+.

Nicotinamide mononucleotide is a direct way to replenish NAD+.

It is by significantly enhancing the ability to repair intracellular DNA damage that nicotinamide mononucleotide ultimately reverses the effects of aging.

Nicotinamide mononucleotide is converted into nicotinamide adenine dinucleotide (NAD), which is essential for energy metabolism in the body. In mouse tests, it has been demonstrated that nicotinamide mononucleotide activates a gene called acetylase in the body, which has been shown to be effective in prolonging life and treating diabetes.

NAD is a substance that can be produced by the human body, and studies have shown that the amount of NAD in the body decreases with age.

Pharmacological Effects of β-Nicotinamide Mononucleotide Raw.

Production method of Bulk β-Nicotinamide Mononucleotide Powder.

Add 150 ml of phosphate buffer solution to a 500 ml four-necked flask. 2 g of magnesium chloride, 10 g of ATP, 7 g of ribose, and 10 g of nicotinamide were added all at once and held at 35°C with stirring. The pH of the reaction system was detected and pH = 8.0 was adjusted with 10% Na2CO3 solution, then 1 g of RK enzyme powder and 2 g of NAMPT enzyme powder were added and stirred to dissolve.

The reaction was stirred at 200 rpm at 37 °C, and the conversion rate of the reaction was monitored using liquid chromatography-mass spectrometry, and after 6 h of reaction, the reaction was stopped by detecting that ATP had been consumed. Through further filtration, HZ-818 type large pore resin adsorption, lyophilization, ethanol and water recrystallization can be obtained β-nicotinamide mononucleotide - nicotinamide mononucleotide NMN, yield 70%

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