Hyaluronic Acid Raw Materials Powder

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Hyaluronic Acid Powder Usage and Synthesis.

Hyaluronic acid effects and functions:

1, has excellent affinity for water, reorganises water inside tissues to better carry loads or lubricate.

2, Folding occurs to form a three-dimensional network that produces physiological effects. These include generating fluid resistance, maintaining water balance and stability of the internal environment in the body, influencing solubility, spatial configuration, chemical balance and systemic osmotic pressure of biomolecules, blocking pathogen playback, and directing the deposition of secretory substances from collagen fibres.

3, Connects with proteins that cannot be separated to form aggregates, maintains the shape and volume of tissues, and ensures the reversible resistance of tissues to compression.

4, have a role in macrophages, mucous cells, lymphocytes, natural killer cells.

5, Hyaluronic acid (HA for short) is an important component of the intercellular matrix and is mainly degraded in the liver.

When liver fibrosis is active, the synthesis of HA increases, coupled with reduced function in cirrhosis, resulting in abnormally high levels of HA in the blood. HA is currently evaluated as a highly sensitive and specific indicator for diagnosing the degree of liver fibrosis and cirrhosis.

Uses and functions of Hyaluronic Acid

Essential drug for ophthalmology "viscous surgery". Used in cataract surgery, its sodium salt is easy to stay in the anterior chamber, so that the anterior chamber to maintain a certain depth, to maintain a clear surgical field of vision, to reduce the occurrence of post-operative inflammation and complications, thereby improving the effect of surgical correction of vision. It is also used in complex retinal detachment surgery. It is also used as an ideal natural moisturising factor, widely used in cosmetics, which can improve skin nutrition and make the skin radiant and tender.

Used as an additive in high-grade cosmetics, also used in medicine

Uses: Used as a moisturising agent in creams, pastes, milks, face masks and serums.

Chemical property of Hyaluronic Acid.

Hyaluronic acid is white amorphous solid, odourless and tasteless, hygroscopic. It is soluble in water and insoluble in organic solvents. The specific rotation of the aqueous solution is -70°-80°.

The most prominent is a high viscosity characteristic, the viscosity of its solution, when the following conditions, an irreversible decline can occur: pH below or above 7; hyaluronidase is present; many reducing substances such as cysteine, pyrogallic gallic acid, ascorbic acid, or the presence of heavy metal ions; (4) ultraviolet light, electron beam irradiation, and so on.

A polymer consisting of the disaccharide repeating unit of (1→3)-2-acetamido-2-deoxy-β-D-glucose-(1→4)-O-β-D-glucuronide, which on hydrolysis produces a hexosamine (e.g., glucosamine) and a glycoalkaloid (e.g., glucuronic acid). Originally used only as a biochemical reagent, it has now become a biochemical drug of high clinical value.

It is found in nature and is widely present in various tissues of animals: connective tissue, umbilical cord, skin, human serum, cockles, synovial fluid of joints, brain, cartilage, vitreous body of the eye, human urine, chicken embryo, rabbit oocytes, walls of arteries and veins. Hyaluronic acid is often bound to proteins and co-exists with other mucopolysaccharides. In vitreous and synovial fluid, it exists in a soluble form, and in cockles and umbilical cords as a gel

Production method of Hyaluronic Acid Powder.

Rooster crowns as raw material to take chicken crowns acetone dehydration, crushed, plus distilled water immersion 24h, fully dissolved, filtration, filtrate with distilled water repeatedly extracted 3 times, combined filtrate, add 100g / L (10%) sodium chloride, dissolved, add an equal volume of chloroform, stirring for 3h, divided into the aqueous phase, and then add 2 times the volume of 95% ethanol precipitation of hyaluronic acid, dehydration, drying, to get the crude product.

Cocktail [acetone] → dehydration broken cocktail [distilled water] → [24h] filtrate [NaCl, chloroform] → aqueous phase [95% ethanol] → hyaluronic acid precipitation → crude product will be dissolved in 0.1mol / L sodium chloride solution, dilute hydrochloric acid to adjust the pH4.5-5, add an equal volume of chloroform stirring, processing 2 times, the aqueous phase with NaOH liquid adjusted to pH7.5, add streptomycin protease 37 ℃ insulation 24h, enzyme solution with chloroform treatment 2-3 times, the aqueous phase plus an equal volume of 10g / L (1%) cetyl pyridinium chloride solution, placed on the precipitation, precipitate plus 0.4 mol / L sodium chloride solution stirring dissociation, centrifugation, separation of the supernatant, with 3 times the volume of 95% ethanol repeated precipitation, dehydration, drying that is, the fine product.

Crude [0.1mol/LNaCl] → dissolution solution [dilute HCl, chloroform] → [pH4.5] aqueous phase [NaOH, keyhole protease] → [pH7.5, 37 ℃, 24h] enzyme solution [chloroform] → aqueous phase [hexadecyl pyridinium chloride] → precipitation [NaCl] → supernatant [95% ethanol] → precipitation → fine products foreign literature reported that distilled water can be used to extract 93% hyaluronic acid from the chickpea 93% of hyaluronic acid was extracted, and the recovery rate of the crude product was above 90%, and the total yield was as high as 6%.

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