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The biochemical pathway to bioactive folate involves a series of enzymatic reactions and cofactors. Absorbed folate is reduced and methylated to 5-MTHF during metabolism in intestinal mucosal cells.
This transformation is limited and does not alter the appearance of folic acid in the blood circulation, where bisabolites are subsequently converted to s-adenosylmethionine (SAMe), a methyl donor involved in a number of biochemical processes. It also serves as a donor for nucleotide synthesis and supports biosynthesis of DNA.
Folic acid deficiency reduces the ability of cells to synthesize and repair DNA, supplementation may be a more beneficial approach to increase folic acid reduces homocysteine levels and supports normal cell proliferation, vascular endothelial function . Cardiovascular disease, neurological function, and especially during pregnancy supplementation with 5-MTHF has been shown to reduce the risk of developing neural tube malformations and recurrences.
Uses of Levomefolate Calcium.
Calcium L-5-methyltetrahydrofolate is a drug that is used to treat anemia, folate deficiency, and tumors. Its main function is to provide folic acid, promote DNA synthesis and inhibit the growth of tumor cells. In addition, Calcium L-5-Methyltetrahydrofolate can also be used to treat folate deficiency caused by folate antagonists such as methotrexate.
Pharmacological effect of Levomefolate Calcium.
Product Method of Bulk Levomefolate Calcium Powder.
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