CDPC Cytidine 5'- Diphosphocholine CAS 987-78-0 Citicoline Powder

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Cytidine 5'-Diphosphocholine powder Usage and Synthesis.

Cytarabine is a mononucleotide composed of nucleic acids, cytarabine, pyrophosphate, and choline, and is used clinically for the treatment of a variety of neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis, and amyotrophic lateral sclerosis. Some studies have also shown that cytarabine can increase the brain's uptake of dopamine and glutamate, thereby improving cognitive performance.

Cytarabine also reduces the release of free fatty acids and restores the activity of mitochondrial ATPase and cell membrane Na+/K+ ATPase, thereby alleviating brain damage.

However, the pathophysiologic mechanisms of neurodegenerative diseases are complex and involve cholinergic deficiencies, glutamate excitotoxicity, neuroinflammation, immune dysregulation, decreased glucose metabolism, and disruption of the blood-brain barrier.

It is mainly used for metabolic disorders after craniocerebral trauma and brain surgery, impaired consciousness, tremor paralysis, neurological deafness and tinnitus, as well as poisoning by sleeping pills. It also has good effect on Parkinson's syndrome and cerebral thrombosis hemiplegia.

Uses and functions of Cytidine 5'-Diphosphocholine powder.

The product is a precursor of lecithin biosynthesis and induces lecithin biosynthesis. The product can promote the recovery and awakening of brain function. It is suitable for the consciousness disorder of traumatic brain injury, post-stroke, etc. It is also used for the consciousness disorder caused by acute injury of central nervous system.

It is used for consciousness disorder after acute craniocerebral trauma and brain surgery. Cerebral thrombosis, multiple cerebral embolism, tremor paralysis, post-stroke sequelae, insufficient cerebral blood supply due to cerebral arteriosclerosis, hypnotic drugs and carbon monoxide poisoning and various organic encephalopathies.

Preparation of Cytidine 5'-Diphosphocholine powder.

There are more methods for the preparation of sodium cytophosphorylcholine, mainly in three ways. One is microbial fermentation method. This method has problems such as low product concentration and unstable yield. One is organic chemical synthesis method. This method has the problems of difficult to separate the product from the condensate, unsuitable for medicinal use, low reaction conversion rate, many by-products, high cost, serious environmental pollution and so on.

There is also an enzymatic synthesis method, such as the use of microorganisms such as brewer's yeast mud for biosynthesis. Enzymatic synthesis using free brewer's yeast mud cells, simple process, high conversion rate, low cost. The production process of synthesizing sodium cytosine by enzymatic synthesis can be divided into two major parts: enzymatic synthesis process and extraction and purification process.

Product Method of Bulk Cytidine 5'-Diphosphocholine powder.

It can be extracted from liver or yeast, or chemically synthesized. Synthesis is achieved by reacting cytosine-5'-diphosphate with ethyleneimine to form cytosine-5'-diphosphate aminoethyl ester, which is then methylated with iodomethane. It can also be obtained by direct condensation of cytosine-5'-phosphate amide with choline phosphate.

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