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It acts on estrogen receptors, preventing their synthesis and reuse, interfering with their binding to estrogen, and inhibiting the growth of tumour cells.
In addition, it can antagonise the glucocorticoid receptor and interfere with the interaction between steroid hormone receptors and regulatory proteins associated with cell growth and differentiation.
Uses of Megestrol Acetate.
Megestrol Acetate Tablets: used in the palliative treatment of hormone-dependent tumours, including endometrial cancer and breast cancer.
Megestrol Acetate Dispersible Tablets: It is a semi-synthetic progesterone derivative, mainly used in the treatment of advanced breast cancer and advanced endometrial cancer, and also has some efficacy in kidney cancer, prostate cancer and ovarian cancer. It can also improve appetite and cachexia in advanced cancer patients.
Megestrol Acetate Capsules / Megestrol Acetate Soft Capsules: It is used in the treatment of advanced breast cancer and advanced endometrial cancer, and also has some efficacy in kidney cancer, prostate cancer and ovarian cancer.
It can also improve appetite and cachexia in patients with advanced tumours.
Pharmacological Effect of Megestrol Acetate.
It is a semi-synthetic progesterone derivative with some inhibitory effect on hormone-dependent tumours.
Its mechanism of action is the same as that of megestrol, probably through the influence on the secretion of pituitary gonadotropin, controlling the development and growth of ovarian follicles, thus reducing the production of oestrogen.
It acts on estrogen receptors, preventing their synthesis and reuse, interfering with their binding to estrogen, and inhibiting the growth of tumour cells.
In addition, it can antagonise the glucocorticoid receptor and interfere with the interaction between steroid hormone receptors and regulatory proteins associated with cell growth and differentiation.
Product Method of Bulk Megestrol Acetate Powder.
The 16,17α-epoxyprogesterone can be debrominated by hydrogen bromide ring-opening and nickel-catalysed reduction to produce 17α-hydroxyprogesterone, which is then acetylated and acid hydrolysed to produce 17α-acetyloxyprogesterone, and then etherified with triethyl orthoformate and reacted with Vilsmeier to obtain 3-ethoxy-6-formyl-17α-acetoxypregnan-2,5-dien-20-one, and then reduced with potassium borohydride, acid hydrolysed, dehydrated, and translocated to obtain this product.
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