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The first generation of cephalosporins was developed earlier, with stronger antibacterial activity, narrower antibacterial spectrum, and better anti-Gram-positive than Gram-negative bacteria. It is stable against β-lactamase produced by Aureobacteria and unstable against β-lactamase produced by negative bacilli, and can still be destroyed by β-lactamase produced by many Gram-negative bacilli.
Cefazolin sodium is a semi-synthetic 1st generation cephalosporin, it has antibacterial effect on both gram-positive and gram-negative bacteria, and is commonly used in respiratory system, genitourinary system, skin and soft tissues, bones and joints, biliary tract and other infections caused by sensitive bacteria, and can also be used in endocarditis, septicaemia, pharyngeal and ear infections it has strong activity against gram-positive bacteria such as Aureus, Streptococcus (except enterococci), and it is better than the second and third generation cephalosporins, It has strong activity against gram-positive bacteria such as Aureus, Streptococcus (except enterococci), which is better than the second and third generation cephalosporins.
Uses and functions of Cefazolin Sodium.
Cefazolin Sodium is used for the treatment of respiratory tract infections such as otitis media, bronchitis, pneumonia, urinary tract infections, soft tissue skin infections, bone and joint infections, sepsis, infective endocarditis, infections of the hepatic and biliary system, and infections of the eye, ear, nose, and throat due to sensitive bacteria.
Cefazolin Sodium can also be used as a prophylactic agent before surgery.Cefazolin Sodium should not be used for central nervous system infections. Cefazolin Sodium is not suitable for the treatment of gonorrhoea and syphilis.
Pharmacological Effect of Cefazolin Sodium.
It is used for the treatment of respiratory tract infections such as otitis media, bronchitis, pneumonia and other respiratory tract infections caused by sensitive bacteria, urinary tract infections, skin and soft tissue infections, bone and joint infections, septicaemia, infective endocarditis, infections of liver and biliary system, and infections of the eye, ear, nose and throat. This product can also be used as a prophylactic drug before surgery.
This product should not be used for central nervous system infections. It is less effective in chronic urinary tract infections, especially those accompanied by anatomical abnormalities of the urinary tract.
It should not be used in the treatment of gonorrhoea and syphilis. Cefazolin sodium is a semi-synthetic 1st generation cephalosporin.
Its mechanism of action is to bind with penicillin-binding proteins (PBPs) on the bacterial cell membrane (mainly with PBP-1, PBP-3), inhibit the synthesis of the bacterial cell wall, and thus play an antibacterial role.
The antibacterial characteristics of this product: the stability of β-lactamase produced by Staphylococcus aureus is better than the 2nd and 3rd generation cephalosporins, and the antibacterial effect on Gram-positive bacteria, including penicillin-sensitive and drug-resistant Staphylococcus aureus (except methicillin-resistant Staphylococcus aureus) is stronger than that of the 2nd and 3rd generation cephalosporins; it is unstable against β-lactamase produced by Gram-negative bacilli, and its action on Gram-negative bacilli is stronger than the 1st generation of cephalosporins. It is unstable to β-lactamase produced by Gram-negative bacilli, and its effect on Gram-negative bacilli is the first among the 1st generation cephalosporins, but not as strong as the 2nd and 3rd generation cephalosporins.
It has good antibacterial effect on Staphylococcus spp (except methicillin-resistant Staphylococcus), Streptococcus pneumoniae, meningococcus, Streptococcus spp, Gonococcus spp. It has antimicrobial effect on Escherichia coli, Streptococcus chrysosporium, anaerobic bacteria, Klebsiella spp. and so on; and it has a certain antimicrobial effect on Haemophilus influenzae (moderately sensitive).
Pseudomonas aeruginosa, Serratia marcescens, Mimicrobium fragilis, indole-positive Proteus, Enterobacteriaceae, Mycoplasma, Enterococcus, Citrobacter, enzyme-producing gonococcus, Chlamydia, and Fusobacterium indolens are resistant to the product.
Drug interactions of Bulk Cefazolin Sodium Powder.
1. This product is contraindicated with the following drugs, not to be injected in the same bottle: Amikacin Sulfate, Kanamycin Sulfate, Chrysomycin Hydrochloride, Hygromycin Hydrochloride, Tetracycline Hydrochloride, Erythromycin Gluconate, Polymyxin B Sulfate, Mucin Methanesulfonic Acid Sodium, Calcium Gluconate.
2. This product can enhance the antibacterial effect in vitro when combined with gentamicin or amikacin.
3. The combination of this product with strong diuretics may increase nephrotoxicity, and the combination with aminoglycoside antibiotics may increase the nephrotoxicity of the latter.
4. Probenecid can increase the blood concentration of this product and prolong the blood half-life.
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