Pharmaceutical intermediate Ambroxol Hcl Powder

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Ambroxol Hcl Powder Usage and Synthesis.

In clinical practice, it can regulate mucus and mucus plasma secretion, activate cilia swing, easy to dilute sputum, strengthen mucus outward transport, easy to discharge, it can also promote the synthesis of lung surface active substances to maintain alveolar tension, to ensure that the functional indicators of the lungs; to promote the penetration of antibiotics into the tissues in order to increase the concentration of enhanced bactericidal effect; antioxidant, reduce the release of inflammatory mediators in order to reduce the inflammatory response; and bronchial antispasmodic substance synergistically, in order to increase the efficacy of antispasmodic drugs.

Therefore, the drug can be widely used in the clinic for acute and chronic respiratory tract disorders accompanied by abnormal secretion of the respiratory tract, especially the expectorant treatment of chronic bronchitis, neonatal respiratory distress and pulmonary surgery adjuvant therapy, with low toxicity, efficacy, and can be used with antibiotics to produce good synergistic effect, as one of the most commonly used expectorant drugs.

Ambroxol Hcl Powder

Uses and functions of Ambroxol Hcl.

Ambroxol hydrochloride is a potent neurogenic sodium channel inhibitor that inhibits TTX-resistant sodium currents with a phasic block and inhibits TTX-sensitive sodium currents with an IC50 of 22.5 μM and an IC50 of 100 μM.

Ambroxol hydrochloride is an antitussive and expectorant drug used in the expectorant treatment of acute and chronic respiratory diseases, especially chronic bronchitis.

Ambroxol Hcl

Pharmacological Effect of Ambroxol Hcl.

1.Anti-cough and phlegm effect of Ambroxol Hydrochloride mainly acts on the respiratory secretory cells, regulating the secretion of mucous and plasma substances, so that the plasma secretion increases, but also cleaves the polysaccharide fibres of acidic glycoproteins in the sputum, inhibits the synthesis of acidic proteins in mucous glands and cup cells, reduces the viscosity of sputum, makes sputum thin and easy to discharge; at the same time, the drug can also increase the frequency and strength of the movement of respiratory tract cilia, and promote the discharge of phlegm and self-cleaning effect of the respiratory Chemicalbook tract. At the same time, the drug can also increase the frequency and strength of respiratory cilia movement, promote sputum discharge and self-purification of the respiratory tract.

2.Antioxidant effect: Ambroxol hydrochloride has obvious antioxidant effect, which plays an important role in reactive free oxygen radicals in lung disease lesions.

Some studies have shown that Ambroxol has a strong inhibitory effect on H2O2 produced by neutrophils; in addition, Ambroxol can activate the intracellular glutathione system and promote the synthesis of intracellular glutathione (GSH), thus counteracting the destructive effect of oxygen free radicals.

Ambroxol Hcl Raw