Pharmaceutical raw materials Decoquinate Powder 18507-89-6

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Decoquinate Powder Usage and Synthesis.

Decoquinate acts during the asexual reproduction stage of the coccidia, entering the ascospores and preventing their development by interfering with DNA synthesis.

It starts to work early in the life history of coccidia, effectively avoiding intestinal damage caused by coccidia. Addition to feed will not affect the digestion of feed and absorption of nutrients by the power.

There are no contraindications to the use of this product; it cannot be used in feeds containing saponified soil. Quinoline anticoccidial drugs are prone to drug resistance, it is recommended to use it only at the peak of coccidial outbreaks, and the longest period of continuous use should not exceed 4 weeks.

Uses of Decoquinate.

Quinoline type coccidiostat. As a feed additive to prevent broiler coccidiosis, add 27.2g of this product to 1t of feed.The product has low toxicity, good tolerance and wide safety range. Rapid metabolism, after stopping the drug for 3 days, the residual drug concentration in each tissue is less than 1ppm.

Pharmacokinetics of Decoquinate.

Absorption is rapid, with effective concentrations of anticoccidials achieved within 1 hour and peak levels reached after 3 days. A single dose of the 14C-labelled product was administered to cattle and sheep at rest after they had been given end-labelled decoquinate for 5 and 7 days, respectively, and peak plasma radioactivity was reached after 1.5 hours.

It was partially metabolised in rats, producing three metabolites, the structure of which could not be determined. In ruminants, only two metabolites were determined and in a lower proportion than in rats.

The main route of excretion in ruminants is faeces, followed by urine. In sheep, 36% of the total dose was excreted in the urine, with 35% excreted within 24 hours and complete urinary excretion of decoquinate and metabolites within 3 days.

Product methods of  Bulk Decoquinate Powder.

3-Hydroxy-4-decyloxynitrobenzene was formed from 3,4-dihydroxynitrobenzene by reaction with bromodecane in DMF medium. Then 3-ethoxy-4-decyloxyaniline was produced by ethoxylation and reduction. Then, 3-ethoxy-4-decyloxyaniline was condensed with diethyl ethoxymethylene malonate to obtain diethyl 3-ethoxy-4-decyloxyanilino-methylene malonate, and finally the finished product was obtained by heating and condensing with heat-conducting Methyl A

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