Food additives γ-Aminobutyric Acid Raw Powder

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γ-Aminobutyric Acid Powder Usage and Synthesis.

Gamma-aminobutyric acid is a strong neuroinhibitory amino acid with sedative, hypnotic, anticonvulsant and hypotensive physiological effects. It is an inhibitory neurotransmitter, which can inhibit the activity of animals and reduce energy consumption.

Aminobutyric acid acts on γ-aminobutyric acid receptor in animal cells, γ-aminobutyric acid receptor is a chloride ion channel, the inhibitory or excitatory property of γ-aminobutyric acid is dependent on the concentration of chloride ions inside and outside of the cell membrane, γ-aminobutyric acid receptor activation leads to the opening of the chloride ion channel, which can increase the permeability of the cell membrane to chloride ions, so that the chloride ions flow into the neuronal cells, causing hyperpolarisation of the cell membrane, inhibiting the neuronal cell element agonism, thus reducing the animal's locomotion.

Uses and functions of γ-Aminobutyric Acid.

It can reduce blood ammonia and promote brain metabolism. Used in the treatment of various types of hepatic coma, also used in post-stroke sequelae, cerebral arteriosclerosis, sequelae of head trauma and uremia, gas poisoning and other causes of coma 4-Aminobutyric acid has the effect of lowering blood lipids and is suitable for the treatment and prevention of various types of hepatic coma. It can be used in the treatment of poliomyelitis, cerebral haemorrhage and as an antidote for gas poisoning. Also used in biochemical research and organic synthesis.

Preparation of γ-Aminobutyric Acid.

Usually produced by pyrrolidone ring-opening. The lime is digested into lime milk with distilled water, pumped into the hydrolysis reactor, add pyrrolidone, raise the temperature to 125 ~ 130 ℃, the reaction pressure is maintained at 0.29MPa, holding reaction for more than 10 ~ 14h.

After the end of the reaction, cool down to 30 ℃ discharge filtration, washed with distilled water.Filtrate with ammonium bicarbonate until no calcium ions detected, and then add activated carbon at 80 ℃ insulation decolorization for 30min, 60 ℃ filtration, washed with distilled water, washings and filtrates combined, at 60 ℃ concentration under reduced pressure until the precipitation of crystals, add ethanol, cooling, filtration, drying,to get the finished product, the yield is more than 85%!

Poduction Method of Bulk γ-Aminobutyric Acid Powder.

1.Synthesis method is produced by pyrrolidone ring-opening. Lime digested into lime milk with distilled water,pumped into the hydrolysis reactor, add pyrrolidone, heating to 125-130 ℃, the reaction pressure is maintained at 0.29MPa, insulation reaction more than 10-14h.

After the end of the reaction, cool down to 30 ℃ discharge filtration, washed with distilled water. Filtrate with ammonium bicarbonate until no calcium ions detected, and then add activated carbon at 80 ℃ insulation decolorization for 30min, 60 ℃ filtration, washed with distilled water, washings and filtrates combined, at 60 ℃ concentrated to precipitate crystals under reduced pressure, add ethanol, cooling, filtration, drying, to get the finished product, the yield is more than 85%.

2. Fermentation method uses Escherichia coli as the strain. Fermentation medium is bran hydrolysate, corn syrup,peptone, magnesium sulfate and sodium chloride. Soya bean oil is used as defoamer, the dosage is about 0.1%, and the fermentation unit is about 100 enzyme units/ml fermentation solution.

In the process of extraction, the use of Escherichia coli decarboxylase, the conversion of L-glutamic acid into γ-ammonia tyrosine in aqueous solution can be dissociated into cations, the use of strongly acidic styrene-based cation exchange resin for ion exchange, ammonia elution, extraction, and then resin purification, concentration,crystallisation, drying and then the finished product.

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