Itraconazole Raw Material Itraconazole Powder

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China Omeprazole Raw Material Itraconazole Powder Factory Supply Itraconazole Raw Material, High Quality Itraconazole Powder Purity 99% Itraconazole Raw Powder CAS 84625-61-6 Itraconazole Raw Powder. Itraconazole Raw Material is a synthetic azole broad-spectrum antifungal used for systemic infections caused by deep-seated fungi, but also for candidiasis and aspergillosis.

Uses and functions of Itraconazole Powder

• 1, For systemic fungal infections such as Aspergillosis, Candidiasis, Cryptococcosis (including Cryptococcal meningitis), Histoplasmosis, Sporotrichosis, Paracoccidioidomycosis Brazil, Bacillariasis, and a variety of other rare systemic or tropical fungal diseases.
• 2, For oral, pharyngeal (foreign information), oesophageal (foreign information), vulvovaginal Candida infections, and fungal conjunctivitis, fungal keratitis.

• 3, Used for superficial fungal infections, such as tinea pedis, tinea corporis, tinea cruris, tinea pedis, and so on.
• 4, For nail fungal diseases caused by dermatophytes and/or yeasts.

Pharmacological Effects of Itraconazole Raw Powder

Itraconazole Raw Materials antibacterial spectrum is wider and stronger than ketoconazole, can inhibit the synthesis of fungal cell membrane ergosterol, so as to play an antifungal effect.Itraconazole Raw Materials against dermatophytes (Trichophyton rubrum, Microsporum spp., flocculent epidermid fungi),

Yeasts [Cryptococcus neoformans, Saccharomyces cerevisiae, Candida (including Candida albicans, Candida glabrata and Candida krusei)], Aspergillus, Histoplasma, Paracoccidioides brasiliensis, Schenk sporotrichum, Stachybotrys, Dendrosporium, Dermatophytes, and a variety of other yeasts and fungi.

Production method of Raw Itraconazole Powder

From m-dichlorobenzene, compound (I) is obtained by a reaction exactly similar to that of ketoconazole. Compound (I) is then condensed with 1-acetyl-4-(4-hydroxyphenyl)piperazine.

It is then hydrolyzed to remove the acetyl group, condensed with p-nitrochlorobenzene, reduced by hydrogenation, chloroformate acylation, then reacted with hydrazine hydrate and then cyclized and alkylated to give itraconazole.

Its intermediate 1-acetyl-4-(4-hydroxyphenyl)piperazine can be piperazine as raw material, prepared by the following reaction.

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