Mature Drug With Antiviral Effect - Leflunomide

Mature Drug With Antiviral Effect - Leflunomide

Introduction of Leflunomide:
Leflunomide is antipyretic, analgesic and anti-inflammatory drug, anti-rheumatoid arthritis drug, CAS : 75706-12-6 MF: C12H9F3N2O2, China Pharmaceutical Active Ingredients Manufacturer supply high quality Leflunomide Raw Material Powder, factory price supply, Guaranteed Customs Clearance.
Leflunomide, also known as Airuhua, Leflunomide, and Dongwa, is an isoxazole immunosuppressant with anti-proliferative activity. Modern pharmacology classifies this product as an antipyretic, analgesic, and anti-inflammatory drug . Because it is difficult to adjust the dose of this product for organ transplant patients, it is mainly used for the treatment of autoimmune diseases such as rheumatoid arthritis. Leflunomide is rapidly converted into active metabolites through the cytoplasm and microsomes of the liver and intestinal wall, and its mechanism of action is mainly to inhibit a key enzyme in the process of DNA synthesis - dihydroorotate dehydrogenase ( DHODH) activity, so that the nucleotides in B lymphocytes are exhausted, the biosynthesis of DNA and RNA is terminated, the cells cannot enter the S phase, and finally cannot proliferate, thereby producing anti-rheumatic effects, suitable for the treatment of adult actives For rheumatoid arthritis and ankylosing spondylitis, it can slow down bone destruction and relieve symptoms and signs. In addition, leflunomide can also inhibit the activity of tyrosine kinase, thereby inhibiting the proliferation of T cells, B cells and non-immune cells, and can also inhibit the biosynthesis of cyclooxygenase-2 (COX2) to inhibit the production of prostaglandins. It plays an anti-inflammatory role in the synthesis of serotonin and inhibits the release of histamine in mast cells and basophils.

Leflunomide has broad antiviral activity, including human immunodeficiency virus-1 (HIV-1), respiratory syncytial virus, cytomegalovirus (CMV), BK polyomavirus (BKV), herpes simplex virus-1 ( HSV), papilloma virus (HPV), Epstein-Barr virus, dengue virus and enterovirus 71, etc., the main mechanism of action is that leflunomide can effectively interfere with the synthesis and assembly of viral envelope or nucleocapsid, and inhibit viral gene The replication of early viral genes and the proliferation of host cells affect intracellular signaling pathways (S6K1, Akt, etc.).

Leflunomide Applied Research:
In addition to treating rheumatoid arthritis, leflunomide can also increase insulin sensitivity.
The research team led by Professor Xu Xiulong from Yangzhou University in Jiangsu Province and Rush University Medical Center in the United States found that in vitro experiments showed that leflunomide can sensitize insulin receptors, suggesting that this drug is not only used for the treatment of rheumatoid arthritis (RA), It may also have a therapeutic effect on diabetes. Type 2 diabetes is a major public health problem. RA patients are often physically inactive and have high levels of circulating inflammatory cytokines, so diabetic patients with RA may have more severe hyperglycemia than patients without RA. Moreover, RA patients were already at significantly higher risk of developing type 2 diabetes and obesity than those without RA. If there is a drug that can control RA and hyperglycemia at the same time, it can greatly improve the condition of patients with both diseases.

Leflunomide Uses:
Leflunomide is a hydrogenated orotate dehydrogenase inhibitor with immunosuppressive and anti-inflammatory properties indicated for the treatment of active rheumatoid arthritis in adults. Anti-inflammatory analgesics, non-steroidal anti-inflammatory drugs. Leflunomide is an anti-rheumatoid arthritis drug.