Methimazole raw Materials Powder

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Methimazole Powder Usage and Synthesis.

Medical treatment of hyperthyroidism

It is suitable for mild cases and those who are not suitable for surgery or radioactive iodine therapy, such as children, adolescents and those who relapse after surgery and are not suitable for radioactive iodine therapy. It can also be used as an adjunct therapy during radioactive iodine therapy.

Treatment of thyroid crisis

In addition to the use of large doses of iodine and other comprehensive measures, large amounts of this product can be used as adjuvant therapy to block the synthesis of thyroxine.

Preoperative preparation

In order to reduce anesthesia and postoperative complications and prevent thyroid crisis after surgery, this product should be taken before surgery to restore thyroid function to normal or close to normal, and then iodine should be added about two weeks before surgery.

Uses of Methimazole.

1. Inhibition of thyroid hormone synthesis: The main mechanism of action of methimazole is to inhibit the peroxidase in the thyroid gland, thus blocking the iodide oxidation and tyrosine coupling in the thyroid gland, and thus inhibiting the synthesis of thyroid hormone and triiodothyronine.

2, Treatment of hyperthyroidism: methimazole is often used to treat mild cases or patients with hyperthyroidism who are not suitable for surgery and are not suitable for radioactive iodine-131 treatment.

3, treatment of thyroid crisis: In addition to being the main treatment of hyperthyroidism, methimazole can also be used as part of the treatment of thyroid crisis, as well as as a preoperative preparation for the prevention of thyroid crisis.

4, reduce the level of thyroid irritant antibodies: Animal experiments have observed that methimazole can inhibit the synthesis of antibodies in B lymphocytes, reduce the level of thyroid irritant antibodies in blood circulation, and restore the function of inhibitory T cells to normal.

5, adjuvant therapy Radioactive iodine therapy: For patients receiving radioactive iodine therapy, methimazole can be used as adjuvant therapy.

Pharmacological action of Methimazole.

Methimazole, like other drugs (propylthiouracil), also has some adverse reactions during administration. These include adverse effects of the hematological system, mainly granulocytosis, arrest or impairment of hematopoietic function, thrombocytopenia, prothrombinopenia, or decreased factor VII; Long-term drug use may also lead to liver damage, including cholestatic jaundice and toxic hepatitis. There are also skin reactions such as hair loss, skin itching, drug rash, dermatitis, lupus erythematosus, and other rare adverse reactions. In addition, methimazole can also prolong prothrombin time, increase serum alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and increase blood bilirubin and blood lactate dehydrogenase. Therefore, patients should regularly test blood items during medication to detect liver function and peripheral blood white blood cell count.

Product Method of Bulk Methimazole Powder.

It is prepared by the reaction of aminoacetaldehyde diethyl alcohol with methyl isothiocyanate. It can also be prepared from the reaction of thiocyanic acid with N-substituted aminoacetal. It can also be prepared from the reaction of thiocyanic acid with N-substituted aminoacetal.

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