Lutein raw Powder Progesterone

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Product details

Lutein Usage and Synthesis.

1, progesterone can maintain the pregnancy of female animals, and lead to a series of physiological changes in pregnant animals, such as inhibiting female estrus.

2, promote the thickening of the uterine mucosa, the curvature of the glands and the increase of secretory function.

3, inhibit the peristalsis of the uterus, and make the cervix contract, secrete viscous liquid, etc. These physiological changes provide suitable environmental conditions for the operation, growth and development of the early embryo and the continued growth of the fetus after implantation.

4. A small amount of progesterone and estrogen cooperate to promote estrus of female animals. Progesterone and prolactin cooperate to promote the development of breast glands.

5. Progesterone is involved in the feedback regulation of hypothalamus and anterior pituitary, so that the secretion of animal reproductive hormones is coordinated and balanced. The amount of progesterone in the body is less than 1 nanogram/ml in the follicular stage of various domestic animals, about 4 nanograms/ml in the luteal stage of cattle, and about 18 nanograms/ml in pregnancy.

Uses of Lutein.

Progesterone has significant morphological effects on estrogen-stimulated endometrium in vivo and is necessary for pregnancy maintenance. In the later period of menstruation, estrogen together with promoting endometrial development and hyperplasia, so that it changes from proliferative stage to secretion stage, creating conditions for fertilized egg implantation and embryo development; Shedding the endometrium completely during menstruation; Inhibit the movement of the uterus and the sensitivity to oxytocin during pregnancy, have the effect of abortion, and together with estrogen promote the further development of the mammary gland to prepare for milk production; Large doses can inhibit the secretion of luteinizing hormone by the anterior pituitary through the feedback regulation of the hypothalamic-anterior pituitary-ovarian axis, thus inhibiting ovulation and playing a contraceptive role. Progesterone can be used for habitual abortion, threatened abortion, functional uterine bleeding, haemorrhagia, dysmenorrhea, endometriosis, amenorrhea, ureteral stones. Prostatic hyperplasia, sleep apnea syndrome and refractory cirrhosis ascites.

Preparation of Lutein.

Product method of Lutein.

It is obtained by oxidation of pregnenolone. Add the dry toluene into the dry reaction pot, add cyclohexanone and pregnenolone, stir to dissolve, steam the toluene to the end of dehydration, quickly add aluminum isopropyl alcohol, oxidation reaction at 115℃ for 2h, cooling to about 80℃, add 5% dilute sulfuric acid under agitation, stand stratification, separate the water layer, toluene layer washed with water to neutral, steam distillation, and steam out toluene and cyclohexanone. Cooling, filtration, filter residue with petroleum ether into a slurry, filter, wash with petroleum ether, dry progesterone crude. The crude product was dissolved in ethanol, decolorized with activated carbon and recrystallized with a yield of 80%.

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