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Epalliprazin is indicated for the treatment of adults with diabetes who do not achieve adequate glycemic control with diet combined with exercise to improve glycemic control. It should not be used to treat patients with type 1 diabetes, elevated ketones in the blood or urine (diabetic ketoacidosis), severe kidney damage, end-stage kidney disease, and dialysis.
Medication Class | Key Benefit | Best For |
---|---|---|
SGLT2 Inhibitors (Empagliflozin) | Heart & kidney protection | Diabetics with CVD/CKD |
GLP-1 Agonists (Semaglutide) | Weight loss & HbA1c control | Obesity + diabetes |
Metformin | First-line, low-cost | Early-stage diabetes |
Insulin | Direct blood sugar control | Type 1 or advanced type 2 |
Pharmacological action of Empagliflozin.
Under physiological environment, the kidney filters and reabsorbs glucose into the circulatory system to maintain the blood glucose balance in the body, while glucose enters the blood through the renal tubule lumen with the cooperation of glucose cotransport protein. SGLT2, as a form of sodium and glucose cotransport protein in glucose cotransport protein, blocks the reabsorption of glucose by the proximal convoluted tubules. Reduces glucose reabsorption by the kidneys and increases the excretion of glucose in the urine, thereby reducing plasma glucose levels. The hypoglycemic effect did not depend on the function of beta cells and was not affected by insulin resistance
A: Yes, most patients lose 2-5 kg due to calorie loss in urine.
A: Yes! They are often combined for better glucose control.
A: Blood sugar drops within hours, but full benefits take weeks.
A: Yes! It actually protects kidney function in most patients.
A: Because it lowers glucose without increasing insulin, reducing hypoglycemia risk.
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