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In order to improve the anti-coccidia effect and reduce the generation of resistance, combination drugs can be taken. In the early stage of coccidiosis (the asexual breeding stage of coccidiosis), the combination of decoxyquinate + diczulide or toltrizulide, diglobulin + maduricin ammonium, diglobulin + cloxypyridine can play a synergistic role, enhance the killing effect, and reduce the dose of each drug by 1/2. In the whole stage of coccidiosis, the combination of dicoccidiol + sulfaquinoxaline sodium and dicoccidiol + sulfachlorpyrazine sodium can be used to inhibit and kill coccidiol in both asexual and sexual breeding stages.
Uses of Decoquinate.
Quinoline coccidium drugs. As a feed additive to prevent coccidiosis in broilers, 27.2g of this product is added to 1t feed. The product has low toxicity, good tolerance and wide safety range. Metabolism is rapid, 3 days after stopping the drug, the residual drug concentration in each tissue is less than 1ppm.
Pharmacological action of Decoquinate.
Product Method of Bulk Decoquinate Powder.
The reaction of 3, 4-dihydroxynitrobenzene with bromodecane in DMF medium to produce 3-hydroxy-4-decyl nitrobenzene. Then, 3-ethoxy-4-decanoxyaniline was prepared by ethoxylation and reduction. Then, 3-ethoxy-4-decanoxy-aniline is condensed with diethyl ethoxymethylmalonate to obtain 3-ethoxy-4-decanoxy-anilinyl methyl-diethyl malonate, which is finally condensed by heat conduction M A to obtain the finished product.
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