Pharmaceutical raw materials Theobromine raw Powder

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Theobromine Usage and Synthesis.

It can be used to improve cerebral circulation after ischemic stroke, and can be used to treat peripheral vascular diseases, such as chronic obliterated vasculitis with intermittent claudication.

Uses of Theobromine.

Theobromine has diuresis, myocardial excitation, vasodilation, smooth muscle relaxation and other effects. Used as a bitters in food processing. Uses Phosphodiesterase inhibitors; Weak adenosine receptor antagonist, smooth muscle relaxant. In medicine, theobromine has diuretic, myocardial excitation, vasodilation, smooth muscle relaxation and other effects.

Preparation of Theobromine.

At present, there are two main methods of producing theobromine, one is extracted from cocoa beans or cocoa bean shells. The other is the theobromine product obtained from monomethyl urea and cyanoacetic acid through condensation reaction, cyclization reaction, nitrosation reaction, reduction reaction, acylation reaction, closed-loop reaction, methylation reaction and double recrystallization.

Product method of Theobromine.

Using methyl urea and ethyl cyanoacetate as starting materials, the crude product was obtained by condensation, nitrosation, reduction, formylation and methylation ring reaction, and then recrystallized.

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