Pharmaceutical raw materials Powder tetrandrine

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tetrandrine powder Usage and Synthesis.

1.Immune system diseasesHantahexin can significantly inhibit the development of arthritis and its effect is stronger than that of aspirin, and it can be used in the treatment of rheumatoid arthritis.

2. Cardiovascular system diseasesHanfengji methylin not only has calcium antagonism, can inhibit the T-type and L-type calcium channels of ventricular myocytes, but also interacts with the M receptor to block calcium-activated potassium channels, which has become a therapeutic method for the treatment of paroxysmal supraventricular tachycardia.

3.Digestive systemHanpaoji Methylin has a role in protecting liver cells and anti-hepatic fibrosis.

4.Ophthalmic diseasesHandukaemonium is used in the treatment of eye inflammation, including uveitis, keratitis and its resulting retinopathy.

5.Other hanfengji methylin has obvious antagonistic effect on the acute nephrotoxic effect caused by streptomycin, can reduce apoptosis and proliferation of renal tubular epithelial cells, protect renal function, and have a protective effect on acute ischemia/reperfusion renal injury, can significantly reduce serum creatinine and urea nitrogen levels, improve glomerular filtration rate and renal plasma flow, and slow down the development of glomerulosclerosis.

Uses of tetrandrine.

Antirheumatic and analgesic, used for rheumatism, high blood pressure, lung cancer, etc.

Pharmacological action of Bulk tetrandrine powder.

1. The preventive and curative effects on hepatic fibrosis, Tet can make the serum type III precollagen, serum and hepatic HA decreased significantly, and the intrahepatic collagen deposition decreased, suggesting that Tet can be used for the treatment of hepatic fibrosis in chronic liver disease.

2.The effect of Tet on hypoxic pulmonary hypertension in hypoxic pulmonary hypertension, Tet can significantly reduce the elevated pulmonary arterial pressure and pulmonary vascular resistance, and can improve the CO and oxygen transport capacity, while the systemic circulation and blood gas level has no significant effect.Tet mainly through the inhibition of collagen fibre proliferation in small pulmonary arteries and inhibition of hypoxia-induced thickening of the pulmonary vasculature and myelination, so that the narrowing of the lumen of small pulmonary arteries was reduced, and the pulmonary pressure was lowered, thus reducing the collagen deposition, suggesting that Tet can be used in the treatment of chronic liver disease of hepatic fibrosis. Tet can reduce the narrowing of small pulmonary artery lumen and lower the pulmonary artery pressure, thus partially inhibiting the development of pulmonary hypertension.

3.Therapeutic effect on silicosisBased on the preparation of cDNA probes for Proα1(Ⅰ) and Proα1(Ⅲ) collagen, the effects of Tet on the mRNA of Ⅰ and Ⅲ collagen genes in silicosis were observed by using spot and in situ molecular hybridisation techniques. It was concluded that the accumulation of collagen in silicosis was caused by the enhanced expression of collagen genes due to quartz dust, and TET could directly or indirectly inhibit the transcription of collagen genes, thus reducing the synthesis of collagen in diseased tissues.

4.Therapeutic effect on hypertensionTet has a significant antihypertensive effect and can significantly reduce the level of lipid peroxides (LPO), thromboxane (TXB2) in the blood of patients with hypertension, significantly increase the level of SOD, prostacyclin (6-keto-PGF1α), and reduce the ratio of TXB2/6-keto-PGF1α. The antihypertensive mechanism of hanfengjiaoxin is due to the blockage of voltage-dependent calcium channels in myocardium and vascular smooth muscle and the elevation of 6-keto-PGF1α level.

Product Methods of tetrandrine.

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