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fusidic acid Powder Usage and Synthesis.

Fusidic acid sodium has excellent tissue permeability and is widely distributed in the body. Of particular clinical importance is the high concentration of this product not only in tissues with abundant blood supply, but also in tissues with low blood vessel distribution. It is known that in pus, sputum, soft tissue, heart, bone tissue, synovial fluid, dead bone fragments, burn scabs, brain abscesses, and eyes, fusidilate sodium concentrations exceed the minimum inhibitory concentration for staphylococcus (0.03 ~ 0.16 µg/ml).

Sodium fusidilate is metabolized in the liver and excreted mainly by bile, with almost no excretion through the kidneys. This product has very low toxicity and no cross-sensitivity with other antibiotics in clinical use, so it can be used to treat patients who are contraindicated with other antibiotics, such as allergic to penicillin or other antibiotics. When prolonged administration is required for severe or deep infections, Fusidilate is recommended in combination with other anti-staphylococcal drugs to reduce the development of resistance. Fusidic acid sodium can be used in combination with penicillin-resistant penicillins, cephalosporins, erythromycin, aminoglycosides, lincomycin, rifampicin, or vancomycin to obtain additive or synergistic effects.

Uses of fusidic acid.

Clinical application is usually made of sodium salt, sodium salt molecular formula C31H47NaO6. Fusidic acid is highly sensitive to a variety of gram-positive bacteria associated with skin infections, especially staphylococcus, is also effective against drug-resistant Staphylococcus aureus, and has certain antibacterial effects against some Gram-negative bacteria. No cross-resistance with other antibiotics.

Pharmacological action of fusidic acid.

Product Method of Bulk fusidic acid Powder.

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