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Naringin has anti-inflammatory, antiviral, anticancer, anti-mutation, anti-allergy, anti-ulcer, analgesic and hypotensive activities, can lower blood cholesterol, reduce the formation of thrombosis, improve local microcirculation and nutrient supply, and can be used for prevention and treatment of cardiovascular and cerebrovascular diseases.
Bile acids act as signaling molecules by activating specific receptors, primarily the Farnesoid X Receptor (FXR) and the Takeda G-protein-coupled receptor 5 (TGR5). These receptors influence a wide array of physiological processes:
Glucose and Lipid Metabolism: Regulation of insulin sensitivity, gluconeogenesis, and cholesterol homeostasis.
Energy Expenditure & Thermogenesis: Modulation of mitochondrial function and adaptive thermogenesis in brown adipose tissue.
Inflammation & Immune Modulation: Exerting anti-inflammatory effects in the liver and gut.
Gut-Liver Axis Communication: Influencing gut microbiota composition and intestinal barrier function.
Uses of biletin.
Tangerine has anti-hemagglutination, anti-thrombus, anti-cancer, anti-fungal, anti-inflammatory, anti-inflammatory, antiviral, anti-cancer, anti-mutation, anti-allergy, anti-ulcer, analgesic, hypotensive activity, lowering blood cholesterol effect.
Biletin Powder is sold strictly as a research chemical for laboratory use only.
Not for Human or Veterinary Consumption: This product is not a dietary supplement, not a food additive, and not approved for therapeutic use in any jurisdiction.
For Research Purposes Only: It is intended for use in controlled laboratory settings by trained scientists. All findings are considered preliminary until validated through extensive clinical trials.
Target Audience: Pharmaceutical R&D departments, university research labs, contract research organizations (CROs), and analytical laboratories.
Pharmacological action of biletin.
Nobiletin is a polymethoxyflavonoid found in some citrus fruits that has a variety of pharmacological effects, including anti-inflammatory, anti-tumor, and neuroprotective properties. A research team led by the University of Ottawa Heart Institute in Canada found through mouse experiments that tangerine can counteract the adverse effects caused by a high-fat diet, thereby improving metabolic disorders and preventing postprandial hyperlipidemia. Previous epidemiological studies have shown that the higher the intake of flavonoids, the lower the cardiovascular risk. Therefore, tangerine should also have the effect of reducing the risk of disease.
Frequently Asked Questions .
Q1: Is Biletin a natural compound or a synthetic one?
A: Biletin is a synthesized derivative of natural bile acids. Its defined chemical structure allows for consistent, reproducible results in research, unlike variable natural bile salt mixtures.
Q2: Can this powder be used to make my own supplements?
A: Absolutely not. This is prohibited and potentially dangerous. Biletin is an unapproved research chemical. Its safety profile for human consumption has not been established. Formulating and consuming it as a supplement is illegal and poses serious health risks.
Q3: What are the main receptors targeted by bile acid derivatives like Biletin?
A: The primary targets are nuclear receptor FXR and membrane receptor TGR5 (GPBAR1). Activation of these receptors triggers cascades that regulate genes involved in bile acid synthesis, lipid/glucose metabolism, and inflammation.
Q4: Are there any published studies on Biletin?
A: Research on specific bile acid derivatives is an active field. Scientists should search scientific databases (e.g., PubMed, SciFinder) using chemical identifiers and related terms ("bile acid derivative," "FXR agonist," "TGR5 agonist") to find relevant preclinical literature that may inform their work.
Q5: How should unused research material be stored and disposed of?
A: Storage: Store in a cool, dry place, protected from light, in its original container. Disposal: It must be treated as chemical waste. Dispose of it according to your institution's hazardous waste disposal protocols and in compliance with all local, state, and federal regulations. Do not pour down the drain or discard with regular trash.
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