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Adapalene Powder Usage and Synthesis.

Adapalene is A retinoic acid compound, which mainly binds to specific retinoic acid nuclear receptors. By normalizing the differentiation of hair follicle epithelial cells, it reduces the formation of micro-acne, and also relieves the inflammatory reaction of acne.

Uses of Adapalene.

Adapalene is a retinoic acid analogue, Adapalene, which is a RARβ and RARγ receptor agonist. Adapalene inhibits cell proliferation and induces apoptosis of colorectal cancer cells in vitro. Adapalene gel is an effective acne treatment.

Pharmacological action of Adapalene.

Adapalene is a retinoic acid compound that has been shown to have anti-inflammatory properties in vivo and in vitro inflammation models, has a stable chemical structure, and does not break down easily under air and light. The mechanism of action is the same as retinoic acid, which can bind to specific retinoic acid nuclear receptors, except that adapalene does not bind to cytoplasmic receptors that bind to proteins. In a skin drug test conducted in an animal model established in mice, adapalene has been shown to treat acne and also has an effect on acne vulgaris and differentiation processes.

The mechanism of action is to reduce the formation of pimples by making the hair cells on the hair follicle differentiate normally. In vivo and in vitro standard anti-inflammatory analyses. The therapeutic effect of adapalene is better than retinoic acid, which can inhibit the chemotactic reaction of human polynuclear leukocytes, and inhibit the metabolism of polymorphic portal by inhibiting the transformation of arachidonic acid into inflammatory mediators through lipid oxidation, so as to alleviate the inflammatory response mediated by cell reaction. It is suitable for the treatment of acne with acne, pimples and pustules as the main manifestations of ordinary type of skin acne. It can also be used to treat acne on the face, chest and back.

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