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Hodgkin's disease (HD) : actinomycin D has outstanding efficacy in the treatment of Hodgkin's disease, especially in the control of fever.
Neuroblastoma: Similarly, actinomycin D has shown remarkable efficacy in the treatment of neuroblastoma.
Choriocarcinoma without metastasis: For the primary treatment of choriocarcinoma without metastasis, the cure rate of with actinomycin D alone is 90% to 100%, and the effect of is similar to that of MTX alone.
Testicular cancer: actinomycin D is also used in the treatment of testicular cancer, is often used in combination with other drugs.
Pediatric nephroblastoma (Wilms tumor) : When used in combination with radiotherapy, improves survival. is also effective for Youwen's sarcoma and rhabdomyosarcoma.
Uses of Actinomycin D.
Actinomycin D is extracted from a kind of actinomycetes isolated from soil after fermentation. In vitro studies have shown that actinomyctin D mainly acts on RNA, and at high concentrations, it affects RNA and DNA synthesis at the same time. The mechanism of action is that it is chimeric in the DNA double strand and binds to its guanine group, inhibits the DNA-dependent RNA polymerase activity, interferes with the transcription process of cells, and thus inhibits mRNA synthesis, that is, it can interfere with the transcription process of mRNA cells in human body, and has therapeutic effects on nerve and nephroblastoma, rhabdomyosarcoma, Hodgkin's disease and testicular tumor, etc. It can also be treated with actinomycin D.
Preparation of Actinomycin D.
Product Methods of Bulk Actinomycin D powder.
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