Pepsin Raw material powder Pepsin

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Pepsin Powder Usage and Synthesis.

Gastric fluid pepsin assay is used to differentiate between neurogenic and gastric hypoacidity, the former sometimes having a normal pepsin level when there is too little or no gastric acid, and the latter having a deficiency of both hydrochloric acid and pepsin.

It is generally accepted that gastric hypoacidity is due to severe organic changes in the gastric mucosa, especially in pernicious anaemia, in the absence of acidosis, and in the absence of pepsin secretion, which is an important diagnostic observation. Pepsin secretion is often reduced in chronic gastritis, chronic gastric dilatation, and chronic duodecolitis.

Uses of Pepsin.

It is mainly used in the manufacture of fishmeal and the hydrolysis of other proteins (e.g. soya protein), in the manufacture of cheese for its curdling properties (in combination with rennet), and in the prevention of cloudiness in the refrigeration of beer. Pepsin is a digestive protease, secreted by the gastricchiefcells in the stomach, which breaks down food proteins into small peptide fragments. The precursor of pepsin is known as pepsinogen. An acidic protease.

A protease extracted from the gastric mucosa of animals. Capable of breaking down peptide bonds in proteins formed by aromatic or acidic amino acids, and therefore catalyses the hydrolysis of casein, globulin, histone, keratin in animal horns, nails, and feathers, as well as plant proteins, etc.

Pharmacological action of Pepsin.

Product Method of Bulk Pepsin Powder.

The product was refined from porcine gastric mucosa, extracted with phosphate buffer, chromatographed on a DEAE-cellulose column, acidified and chromatographed again on Sephadex C-25 and Sephadex G-25 columns.

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