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DL-selenomethionine, as a natural organic selenium source in living organisms, is now gradually replacing inorganic compounds such as sodium selenite as a good source of selenium supplementation and an intermediate in the preparation of other selenium-containing drugs, and has become a focus of selenium compounds development.
Uses of Selenium Methionine.
Used as pharmaceutical and healthcare intermediates, feed additives.
Synthesis method of Selenium Methionine.
Synthesis of crude DL-selenomethionine sodium salt: an alkali metal carbonate-containing alcoholic solvent is used as the reducing reaction medium, and said alkali metal carbonate-containing alcoholic solvent is one or a combination of methanol, ethanol, propanol, isopropanol, butanol containing potassium carbonate or/and sodium carbonate, and the purified dimethyldiselenomethionyl ether of step (2) is reacted with hydrazine hydrate and a catalyst at the temperature of 5~15°C for 0.5~2h Generate sodium methylselenol, hydrazine hydrate and dimethyldiselenide molar ratio of 1 to 2, and then sodium methylselenol, as well as Figure methylselenol sodium molar ratio of 1 to 1.5 α-amino-gamma-butyrolactone hydrobromide heated to 60 to 65 ℃ reflux reaction 6h after adding to the DL-selenomethionine counting molar ratio of 0.5-500 water for hydrolysis, and adjust the pH value of 5-6, dehydration to get DL-seleno methionine sodium salt crude product, wherein said catalyst comprises carbon powder and/or ferric chloride, and the molar ratio with dimethyl diselenide is 0.05 to 0.1
Product Method of Bulk Selenium Methionine Powder.
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