L-5-methyltetrahydrofolate raw Materials Powder Levomefolic Acid

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L-5-methyltetrahydrofolate Powder Usage and Synthesis.

5-Methyltetrahydrofolate is the most biologically active and functional form of folic acid, the only way for folic acid to participate in physiological metabolism, and the only form of free folic acid present in animal plasma and cells.

It is mainly used as an active ingredient in pharmaceuticals and as a food additive, with applications in the prevention of foetal neural tube defects, atherosclerosis, the treatment of megaloblastic anaemia, the enhancement of the therapeutic effect of pyrimidines fluoride, and the treatment of autoimmune diseases such as psoriasis and rheumatoid arthritis.

Uses of L-5-methyltetrahydrofolate.

Ordinary folic acid supplements, i.e. inactive form of folic acid (folicacid), need to be converted into active form of folic acid structure (5-methyltetrahydrofolate) to play a biological role in vivo through genes and related metabolism, and the efficiency of the conversion into 5-methyltetrahydrofolate that can be absorbed by the human body is extremely low, and also prone to loss of folic acid in the raw material processing process.

Widespread research in China has shown that there is a higher percentage of mutation defects in the MTHFR (a key gene for the conversion of active folic acid in vivo) gene in China than in Europe and the United States, resulting in a failure to efficiently convert active folic acid metabolism into action and causing cellular dysfunction.

MTHFR gene mutation patients need to pay more attention to the daily supplementation of active folic acid, effective absorption and utilisation.

Application Areas of L-5-methyltetrahydrofolate.

5-Methyl tetrahydrofolate is the most biologically active and functional form of folate, representing the sole pathway through which folate participates in physiological metabolism. It is also the only form of free folate present in animal plasma and cells.
It is primarily used as an active pharmaceutical ingredient and food additive, with applications including the prevention of foetal neural tube defects and atherosclerosis, the treatment of megaloblastic anaemia, enhancing the therapeutic effects of fluoropyrimidines, and the treatment of autoimmune diseases such as psoriasis and rheumatoid arthritis.

Function of Bulk L-5-methyltetrahydrofolate Powder.

Ordinary folic acid supplements are non-active forms of folic acid (folic acid) that need to be converted into active forms of folic acid (5-methyl tetrahydrofolate) through genes and related metabolism in the body to exert their biological effects. The efficiency of conversion into 5-methyl tetrahydrofolate, which is absorbable by the human body, is extremely low, and folic acid is easily lost during the processing of raw materials.

Research widely conducted in China indicates that the prevalence of MTHFR gene mutations (a key gene involved in the conversion of active folate) is higher in China than in Western countries, leading to ineffective conversion and utilisation of active folate, resulting in cellular dysfunction.

5-Methyl tetrahydrofolate can cross the blood-brain barrier and be effectively absorbed and utilised by the brain, making it the preferred form of active folate for human absorption and utilisation. Individuals with MTHFR gene mutations should pay particular attention to supplementing with active folate to ensure effective absorption and utilisation.

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