Supplements Berberine Hydrochloride 97% powder Berberine Hcl

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Product details

Berberine Hcl powder Usage and Synthesis.

Berberine has antibacterial effects on hemolytic streptococci, Staphylococcus aureus, gonococci, and Shigella dysenteriae, and enhances the phagocytosis of leukocytes. Berberine hydrochloride (commonly known as berberine hydrochloride) has been widely used to treat gastroenteritis, bacterial dysentery, etc., and also has certain effects on tuberculosis, scarlet fever, acute tonsillitis and respiratory tract infections.

Uses of Berberine Hcl powder.

It has a weak inhibitory effect on bacteria (mainly dysentery, Escherichia coli, Staphylococcus aureus), and reduces the number of pili on the surface of bacteria, making it difficult for bacteria to attach to human cells, and can alleviate gastric and duodenal peptic ulcers.

Mainly used as a raw material for gastroenteritis, bacillary dysentery and other intestinal infections caused by sensitive pathogens.

Pharmacological effect of Berberine Hcl powder.

It has a broad antibacterial spectrum and has an in vitro antibacterial effect on a variety of Gram-positive and Gram-negative bacteria, including hemolytic Streptococcus, Staphylococcus aureus, and Vibrio cholerae. It has a strong inhibitory effect on meningococci, Shigella dysenteriae, Salmonella typhi, and Corynebacterium diphtheriae. It has an inhibitory effect at low concentrations and a bactericidal effect at high concentrations.

It also has a certain inhibitory effect on influenza virus, amoeba, leptospira, and certain skin fungi. In vitro experiments have confirmed that berberine can enhance the phagocytic ability of white blood cells and the liver reticuloendothelial system. Shigella dysenteriae, hemolytic Streptococcus, Staphylococcus aureus, etc. are very likely to develop resistance to this product.

Product method of Bulk Berberine Hcl powder.

1. Natural extraction method

‌ Plant raw material processing‌
Use plants such as Coptis chinensis and Phellodendron chinense as raw materials, chop them and extract them with ethanol or ethyl acetate, filter and concentrate to obtain crude extracts
Using ultrasonic assisted extraction can improve efficiency (short extraction time, high yield, suitable for heat-sensitive components)

‌ Purification process‌
The crude extract is washed with ether to remove impurities, then recrystallized with a benzene-water mixed solvent, and berberine hydrochloride is obtained after acidification with hydrochloric acid
The solvent can be recycled in the environmentally friendly process to achieve clean production

2. Chemical synthesis method

‌Key synthesis route‌
‌Route A‌: 5-halogenated o-veratraldehyde and piperonyl ethylamine are used as starting materials, and the synthesis is carried out through condensation, amination, cyclization and other steps
‌Route B‌: Synthesis through methyl compound → condensation compound → berberine hydrochloride final product (purity can reach 99.8%, single impurity <0.1%)

‌Process advantages‌
Raw materials are cheap and easy to obtain, reaction conditions are mild (no high temperature and high pressure), and heavy metal catalyst pollution is avoided
Suitable for industrial production, less waste and high safety

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