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Beta-nicotinamide mononucleotide is the precursor substance of NAD+, a cofactor of longevity proteins in the human body.
NAD+ is an important coenzyme of the tricarboxylic acid cycle, which promotes the metabolism of sugars, fats, and amino acids, and participates in the synthesis of energy; NAD+ is also the only substrate for the coenzyme I depletion enzymes (the only substrate for the DNA repair enzyme PARP, the only substrate for the longevity proteins Sirtuins, and the only substrate for the cyclic ADP-ribose synthetase CD38/157).buy nicotinamide mononucleotide nmn supplement online
NAD+ is involved in all aspects of human metabolism and is a key coenzyme. Without NAD+, metabolism will not work, and the elderly lack NAD+, so all kinds of big and small problems come, and by supplementing NAD+ additionally, it can be a comprehensive anti-aging.nicotinamide mononucleotide nmn Amazon
Preclinical studies have shown a variety of pharmacological activities of NMN in cardiac and cerebral ischemia, Alzheimer's disease, dietary and age-induced type 2 diabetes and obesity, NMN as a precursor drug for NAD+, mainly synthesized in the body to play a pharmacological role in the synthesis of NAD+, all of which are related to the lack of NAD+.
Uses and functions of Nicotinamide Mononucleotide powder.
In mammals, β-nicotinamide mononucleotide is produced from nicotinamide (Nam) catalyzed by Nampt (a protease in vivo), and subsequently nicotinamide mononucleotide is catalyzed by nicotinamide mononucleotide adenylyltransferase to produce NAD+. Nicotinamide mononucleotides are a direct way to replenish NAD+.
It is by significantly enhancing the ability to repair intracellular DNA damage that nicotinamide mononucleotide ultimately achieves the reversal of aging. Nicotinamide mononucleotide is converted into nicotinamide adenine dinucleotide (NAD), which is essential for energy metabolism in the body.
In mouse tests, it has been shown that nicotinamide mononucleotide can activate a gene called acetylase in the body, thus exerting such effects as prolonging life and treating diabetes, etc. NAD is a substance that the human body can originally produce, and studies have confirmed that the amount of NAD in the body decreases with age.
Efficacy and Application of nicotinamide mononucleotide supplement
β-Nicotinamide mononucleotide (NMN) has shown effective therapeutic effects in animal models of diseases such as diabetes, cerebral ischemia, and Alzheimer's disease, mainly by stimulating the synthesis of NAD+. Compared with direct NAD+ administration, NMN administration is easier to penetrate the cell membrane, not only better exerting its pharmacological activity, but also avoiding side effects such as anxiety and insomnia caused by high-dose NAD+ intake. In addition, NMN can also effectively treat cerebral hemorrhage, reduce fat and lose weight, repair DNA damage, improve dark vision and retinal function, improve mitochondrial energy status, and promote neurovascular regeneration.
Synthesis of nicotinamide mononucleotide nmn
Currently, exogenous NMN production methods primarily fall into two categories: chemical synthesis and biological methods. The former, which was studied earlier, primarily utilizes nicotinamide and ribose as raw materials through various synthetic steps. However, its complex technical route, harsh reaction conditions, high production costs, and low product yield and purity significantly limit its application and widespread adoption. Compared to chemical synthesis, biological methods offer advantages such as a simpler technical route, convenient operation, environmental friendliness, and low production costs.
Chemical Methods
① Bromoacetylribose Method
The bromoacetylribose method has a four-step reaction process.
② TMSOTF-catalyzed condensation method: Nicotinamide (NAM) undergoes a condensation reaction with the hydroxyl-protected ribose and the catalyst TMSOTF to produce a mixture of α- and β-NMN. β-NMN can be obtained by separation on an activated carbon column.
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