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D-Tryptophan is an important amino acid with a wide range of applications.
Currently, the major global producers of D-Tryptophan include Kyowa Fermentation Industry Co., Ltd. of Japan, Ajinomoto Co., Ltd. of Japan, and Hijack Group of Korea.
The applications of D-Tryptophan in the pharmaceutical industry include being used as raw material for synthetic drugs, such as antidepressants and anti-allergy drugs. In addition, D-Tryptophan is widely used in the food industry, such as beverages, confectionery, baked goods and so on.
Uses of D-tryptophan.
D-Tryptophan, as a non-protein active amino acid with special physiological properties, can be used as a non-nutritive sweetener, feed additives, plant growth agents in the food and feed industry as well as in agriculture. In the pharmaceutical industry, it is mainly used for the synthesis of a variety of polypeptides, instead of L-Tryptophan to extend the half-life of peptide drugs and reduce the side effects, do not produce resistance to become an important synthetic precursor to enzyme inhibitors.
It can improve the body's immune ability and delay the occurrence of allergic reactions. Most of the peptide antibiotics can be anti-Gram-positive bacteria, but also some have better inhibition or killing effect on Gram-negative bacteria such as Pseudomonas aeruginosa, Mycobacterium, fungi, pathogens, germs and tumor cells.
Physiological effect of D-tryptophan.
Product method of Bulk D-tryptophan Powder.
Take DL-tryptophan as raw material, add chloroacetic anhydride under cooling state to react, after acidification by sulfuric acid, grind in ice water, filter and recrystallize in water, finally treat with pancreatic carboxypeptidase to remove L-type, and refined by acidification by acetic acid and recrystallization by ethanol.
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