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Methylfolate (L-methylfolate) is a biologically active form of folic acid that is important in the treatment of diseases such as diabetic neuropathy.
However, some products may list only methylfolate or 5-MTHF without specifying the form it contains. If the label does not clearly indicate L-Methylfolate, Metafolin or Quatrefolic, it may not be the biologically active form.
In addition, some drugs and food additives may interfere with the absorption and utilization of methylfolate, such as cephalosporin antimicrobials, sulfonamides, H2 receptor antagonists, and proton pump inhibitors. In order to fully utilize the benefits of methylfolate, it is recommended to consult a physician or dietitian for advice before use. Also, folic acid supplementation can significantly reduce the incidence of autism and neural tube defects.
Uses of 5-Methyltetrahydrofolic acid.
Methylfolate is a vitamin B9 supplement that can be used to treat depression, mixed seizures, and other conditions. However, it may interact with many medications, so it is important to talk to your doctor before using it. In addition, some people may experience unwanted side effects such as nausea, vomiting, and headaches .
Supplementation with methylfolate may also lead to an increase in unmetabolized folate, which can inhibit 5-methyltetrahydrofolate in breast milk. In addition, baker's yeast and nutritional yeast contain B vitamins, including folic acid.
L-Methylfolate vs. L-5-Methyltetrahydrofolate
| Feature | L-Methylfolate | L-5-Methyltetrahydrofolate |
|---|---|---|
| Chemical Identity | This is the common or simplified name for the ingredient. | This is the complete, precise, systematic chemical name for the ingredient. |
| What Is It? | An active form of folate that your body can use directly, bypassing the need for conversion by the MTHFR enzyme. | The exact same molecule as L-Methylfolate. "L-5-MTHF" is its full name. |
| Core Value | Bypasses MTHFR gene mutations, providing "ready-to-use" folate to support homocysteine metabolism and neurological health. | Identical to L-Methylfolate. |
| User Pain Points | "My genetic test showed an MTHFR mutation, and my doctor said to get active folate, but I don't know which one to buy." | "This ingredient name is so complicated! Is it the same thing as L-Methylfolate? Did I buy the wrong one?" |
| Brand Examples | The most common marketing name. Many brands use "L-Methylfolate" as the key selling point. | May appear in the ingredient list or scientific literature for precision. Some brands may use "L-5-MTHF." |
| What You Should Focus On | Do not be tricked by the names into thinking they are different ingredients. Your core task is not to choose between these two, but to ensure the product you buy contains either form of active folate, not ordinary synthetic Folic Acid. |
Folic Acid: A synthetic compound not found in nature. It is used in most supplements and fortified foods (e.g., bread, cereal). Your body must convert it into active folate (like 5-MTHF) through a multi-step process.
5-MTHF (e.g., L-methylfolate): The active, natural form of folate found in foods like leafy greens, legumes, and eggs. It is ready for your body to use immediately, bypassing the need for conversion.
| Feature | Folic Acid | 5-MTHF (Active Folate) |
|---|---|---|
| Form | Synthetic, oxidized compound | Natural, reduced, and active form |
| Bioavailability | Requires conversion in the liver (a multi-step process) | Directly usable by the body; no conversion needed |
| MTHFR Gene Impact | Inefficient conversion in people with MTHFR mutations (~30-60% of the population) | Bypasses the mutation; effective regardless of genetics |
| Safety Profile | High doses may lead to unmetabolized folic acid in the blood, linked to potential health risks | No risk of unmetabolized accumulation; generally safer at high doses |
| Primary Use | Fortified foods and low-cost supplements | Targeted supplements for MTHFR mutations, pregnancy, and mood support |
Individuals with a known or suspected MTHFR mutation.
Those experiencing side effects or inefficacy from folic acid.
People seeking the most bioavailable and natural form of folate.
Women planning pregnancy or taking prenatal supplements (under medical guidance).
Our advantage
We possess extensive experience, handling every step from sourcing each ingredient in the formulation to post-filling inspection, all at the most competitive prices and with the fastest delivery times.
InterlGroup owns factory, Main Product Foods additives, Nutritional supplements, Healthcare Products(capsules,Softgels,tablets,Gummies,Liquid Drops,Gum,solid beverage and other customized products), plant extracts.
Support OEM&ODM service，Design label packaging, Overseas in stock, Fast customization, Drop Shipping.
Intergroup is supplying OEM service for the Well-known brands Reson and Ausreson.
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