Citicoline sodium raw Powder CAS 33818-15-4

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Citicoline sodium Usage and Synthesis.

Cytarabine Sodium is a nucleoside derivative, mainly used to improve brain tissue metabolism, promote brain function recovery and awakening. It is mainly used for acute craniocerebral trauma and brain surgery-induced disorders of consciousness, but also for other functional and conscious disorders caused by acute injury to the central nervous system. In addition, cytarabine sodium is also used in the treatment of ischemic cerebrovascular disease and vascular dementia.

Uses of Citicoline sodium.

Coenzyme. For acute craniocerebral trauma and brain surgery after consciousness disorder. Acute craniocerebral trauma and brain surgery after consciousness disorders, for hemiplegia due to cerebral stroke can gradually restore the function of the limbs, but also can be used for other acute injury to the central nervous system caused by the function and consciousness disorders, but also used for ischemic cerebrovascular disease and vascular dementia .

Cytidine 5'-di-choline phosphate (CDP-choline), which supports lecithin synthesis, is produced by choline-phosphate cytidylyltransferase EC 2.7.7.15; used to study its role in neurorehabilitation.

In vitro effect of Citicoline sodium.

Citicoline is a major component of cell membrane phospholipids, a complex organic molecule composed of ribose, pyrophosphate, cytosine and choline.

Citicoline is water soluble and its oral bioavailability is greater than 90%. citicoline has no mitogenic or chemotactic effect on hCMEC/D3. However, it significantly enhances wound healing, sphere germination, and strongly induces the formation of endothelial tubular structures in the basement membrane matrix.

Citicoline induces the expression of phosphorylated ERK1/2. It protects hCMEC/D3 from cell injury/apoptosis.Citicoline induces vascular neovascularization and improves the survival of human brain microvascular endothelial cells through the p-ERK1/2 and IRS-1-related pathways.

Product Method of Citicoline sodium.

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