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Troxerutin Powder Physiological effect.Tricerutin (TiOxerutin) can inhibit platelet aggregation, and has the effect of preventing thrombosis. At the same time, it can counteract the vascular damage caused by 5-trans-tryptamine and bradykinin, increase capillary resistance and reduce capillary permeability, which can prevent oedema caused by elevated vascular permeability. It has significant protective effect on acute ischaemic brain injury.
Troxerutin has anticoagulant and thrombosis-preventing effects, and is suitable for the treatment of hemiplegia due to cerebral thrombosis, aphasia, arteriosclerosis, thrombophlebitis, varicose veins, chronic venous insufficiency, central retinitis, diabetic retinitis and oedema caused by elevated vascular permeability.
Uses and Function of Troxerutin.
Used as anticoagulant, with the effect of preventing thrombosis, applicable to cerebral thrombosis and cerebral embolism caused by hemiplegia, aphasia and myocardial infarction, arteriosclerosis, etc.
Treatment of cerebral thrombosis and cerebral embolism caused by hemiparesis, aphasia, and pre-myocardial infarction syndrome, arteriosclerosis, central retinitis, thrombophlebitis, varicose veins, and oedema caused by elevated vascular permeability.
In addition, Troxerutin has antioxidant, anti-inflammatory and anti-tumour effects. It should be noted that although the names of compound rutin tablets and traxerutin tablets are similar, their chemical structures, physicochemical properties, pharmacological effects as well as indications are very different[2. When using the drugs, they should be used correctly according to the doctor's advice to avoid misuse or overdose.
Pharmacological Effect of Troxerutin.
Troxerutin can inhibit platelet aggregation and has the effect of preventing thrombosis. At the same time, it can counteract the vascular damage caused by 5-hydroxytryptamine and bradykinin, increase capillary resistance and reduce capillary permeability, which can prevent oedema caused by elevated vascular permeability.
Product Method of Bulk Troxerutin Powder.
Triclabrutin can be made into suitable soft material with starch as filler and 95% ethanol as wetting agent, granulated and dried and then rectified with nylon sieve bottom, and then pressed into tablets after mixing with magnesium stearate and talc as lubricant. Its appearance is smooth and delicate, the tablet hardness is good, the tablet weight difference is stable, and the content is qualified.
This process can improve the fluidity and outflow speed of Troxerutin powder, make the outflow speed of the particles fast flow rate uniformity, so as to ensure the stability of the tablet difference, and at the same time, the granulation can reduce the amount of fine powder, reduce the powder and the opportunity to contact with the punch rod, avoiding the phenomenon of pulling the mould.
This process does not require drying less energy consumption, low cost, suitable for industrial production.
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