Glipizide raw materials Glipizide Powder

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Glipizide Powder Usage and Synthesis.

Glipizide1, chemically known as N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methylpyrazine-2-carboxamide, is a second-generation oral hypoglycemic drug of the sulfonylurea class developed by Pfizer, which was listed on the U.S. market in 1984, and was listed on the domestic market in 2010 in the sustained-controlled-release formulation, under the trade name of Ruiyanin.

It can promote the secretion of insulin by pancreatic β-cells and enhance the effect of insulin on target tissues; it can also inhibit the secretion of glucagon by pancreatic α-cells, inhibit the decomposition of hepatic glucose, and promote the use of glucose by muscles and consumption.

It is clinically used for patients with mild to moderate type 2 diabetes who cannot achieve good results with dietary control therapy alone.

Uses and functions of Glipizide.

It is suitable for patients with mild or moderate type 2 diabetes mellitus whose efficacy is unsatisfactory after 2 to 3 months of dietary control and physical exercise. These diabetes mellitus patients need to have a certain degree of insulin-secreting function of pancreatic β-cells and have no acute complications (e.g., infections, traumas, ketoacidosis, hyperosmolar coma, etc.), are not associated with pregnancy, and do not have serious chronic complications.

Pharmacological Effect of Glipizide.

1. Hypoglycaemic effect: This product is the second generation of oral sulfonylurea hypoglycaemic drug, which has a precise effect on type II non-insulin diabetes mellitus.

It acts on pancreatic β-cells and promotes endogenous insulin secretion; inhibits hepatic glycogenolysis and promotes the use of glucose in peripheral tissues; it can also change the sensitivity of insulin target tissues to insulin through extra-pancreatic action, which may be related to the increase of plasma cell membrane insulin receptor and post-receptor effect.

2. Reduce serum triglyceride level and accelerate the conversion of cholesterol within the blood.

3. Reduces platelet cohesion and improves the breakdown and absorption of fibrin.

Product Method of  Bulk Glipizide Powder.

N-[4-(aminosulfonyl)phenyl]ethyl-5-methylpyrazine-2-carboxamide was prepared by condensation of 5-methylpyrazine-2-carboxylic acid with 4-(2-aminoethyl)benzenesulfonamide, and glipizide was obtained by esterification of N-[4-(aminosulfonyl)phenyl]ethyl-5-methylpyrazine-2-carboxamide with cyclohexyl isocyanate.

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