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Product details
Cefotaxime sodium is a commonly used carbapenem antibiotic, belongs to the third generation of semi-synthetic cephalosporins, the antibacterial spectrum is broader than cefuroxime, the role of gram-negative bacteria is stronger, the antibacterial spectrum includes haemophilic influenza bacillus, Escherichia coli, Escherichia coli, Salmonella Klebsiella spp. and Aspergillus exoticus, Neisseria spp. Staphylococcus, Pneumococcus, Streptococcus, Klebsiella and Salmonella spp. and other intestinal bacteria. Enterobacteriaceae and Salmonella.
Cefotaxime sodium has no antibacterial activity against Pseudomonas aeruginosa and alkali-producing bacilli, poor antibacterial activity against Staphylococcus aureus, strong activity against gram-positive cocci such as haemolytic Streptococcus, Streptococcus pneumoniae, and enterococci spp. (Enterococcus inguinalis, Enterobacter aerogenes) are resistant to this product.
Clinically, cefotaxime sodium can be applied to pneumonia and other lower respiratory tract infections, urinary tract infections, meningitis, sepsis, abdominal infections, pelvic infections, skin and soft tissue infections, reproductive tract infections, bone and joint infections caused by sensitive bacteria.
Cefotaxime can be used as an optional drug for paediatric meningitis.
Uses and functions of Cefotaxime sodium.
The third generation of broad-spectrum cephalosporin antibiotics, on the gram-negative and positive bacteria have a strong bactericidal effect, especially on gram-negative bacteria, stable to β-lactamase, must be injected to give drugs.
Clinically used for respiratory infections caused by sensitive bacteria, urinary tract infections, biliary tract and intestinal infections, skin and soft tissue infections, sepsis, burns and bone and joint infections.
Mainly used for the treatment of respiratory system, urinary system, intestinal and biliary tract, skin and soft tissue, burns and bone and joint infections caused by sensitive bacteria.
Characteristic of Cefotaxime sodium.
White, off-white or yellowish-white crystals, odourless or with special smell.
Soluble in water, slightly soluble in ethanol, insoluble in chloroform. Dilute solution is colourless or slightly yellow, greyish yellow when concentration is higher, dark yellow or brown when deteriorated. It is colourless or slightly yellowish in dilute solution.
Melting point 162～163°C (decomposition). [α]D20+56°～+64° (10mg of this product dissolved in Iml water): [α]D20>+55°±2° (C=0.8, water).
Poduction Method of Bulk Cefotaxime sodium Powder.
8g of sodium bicarbonate was dissolved in 20ml of ethanol, 45.55g of 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]cephalosporin-3 slightly-4-carboxylic acid (cefotaxime) dissolved in 100ml of distilled water was added successively to the solution formed in 100ml of distilled water, and then added to 80rnl of ethanol and 4.5g of activated charcoal, stirred for 5min, and then filtered. The filter cake was washed with ethanol and the filtrate was concentrated under reduced pressure to to, the residue was dissolved in: 100 ml of ethanol and concentrated to dryness.
The residue was dissolved in 100ml of methanol and poured into 2L of acetone. The resulting solution was stirred vigorously and filtered under reduced pressure, the solid was washed slightly first with acetone and then with ether, and dried in vacuum to give 43.7 g of white sodium cefotaxime. This cefotaxime sodium was hygroscopic in air and weighed 45.2 g after hygroscopy as a hydrate of cefotaxime sodium.
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