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Ciprofloxacin hydrochloride is indicated for urinary tract infections, moderate and severe respiratory tract infections, intestinal infections, skin and soft tissue infections, sepsis and intra-abdominal infections caused by sensitive bacteria.
Uses and functions of Ciprofloxacin Hydrochloride.
Ciprofloxacin hydrochloride is one of the excellent representatives of quinolone antimicrobials, which was successfully developed by Bayer Pharmaceuticals, Germany in 1983.The first generation of quinolone antimicrobials is represented by nalidixic acid, the second generation is represented by piperic acid, and the third generation is represented by haloperidol. Cyclopropyl haloperidol has a wide antibacterial spectrum, strong antibacterial activity, and is effective against both Gram-positive and Gram-negative bacteria, as well as Pseudomonas aeruginosa, with few adverse reactions. It is a variety of drugs with large sales in the international market, and the domestic production is developing rapidly.
Pharmacological Effect of Ciprofloxacin Hydrochloride.
1, Ciprofloxacin hydrochloride has a broad-spectrum antibacterial effect, especially on aerobic gram-negative bacilli with high antibacterial activity, the following bacteria in vitro with good antibacterial effect: Enterobacteriaceae most of the bacteria, including Bacillus bacillus, inguinae, Enterobacteriaceae, Enterobacter aerogenes and other Enterobacteriaceae, Escherichia coli, Klebsiella, Aspergillus spp. Salmonella spp., Shigella spp. Vibrio spp. Yersinia spp.
It often has antibacterial activity against multi-drug resistant bacteria. It has high antibacterial activity against penicillin-resistant Neisseria gonorrhoeae, enzyme-producing influenza bacteria and Moraxella catarrhalis.
It has antibacterial activity against most strains of Pseudomonas aeruginosa and other Pseudomonas species.
Ciprofloxacin hydrochloride has antibacterial activity against methicillin-sensitive staphylococci, and only moderate antibacterial activity against Streptococcus pneumoniae, Streptococcus haemolyticus and Enterococcus faecalis.
It has good antimicrobial activity against Chlamydia trachomatis, Mycoplasma, Legionella, and also against Mycobacterium tuberculosis and atypical mycobacteria. The antibacterial activity of anaerobic bacteria is poor.
2, Ciprofloxacin is a bactericide, through the action of bacterial DNA helicase A subunit, inhibit DNA synthesis and replication and lead to bacterial death.
Product Method of Bulk Ciprofloxacin Hydrochloride.
3-Chloro-4-fluoroaniline was diazotised and replaced to produce 2,4-dichlorofluorobenzene, which was then acetylated to obtain 2,4-dichloro-5-fluoroacetophenone, and ethyl 2,4-dichloro-5-fluorobenzoylacetate was prepared by condensing it with diethyl carbonate, and then reacted with triethyl orthoformate, acetic anhydride, and cyclopropylamine in a stepwise reaction to make 2-(3,4-dichloro-5-fluorobenzoyl)-3-cyclopropylaminopropenoic acid ethyl ester, the latter reacted with NaH in anhydrous dioxane and refluxed for 2h to produce 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, and finally reacted with aqueous piperazine to obtain cyclopropylpiperazine
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