Veterinary Medicine Anthelmintics Praziquantel / Biltricide Powder CAS 55268-74-1 Raw Materials

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Praziquantel / Biltricide Powder Usage and Synthesis.

Praziquantel Powder (praziquantel) is a synthetic drug for broad-spectrum deworming discovered abroad in the 1970s.

Biltricide Powder has a significant killing effect on adult Schistosoma haematobium.

Praziquantel Raw Materials is a commonly used drug for the treatment of schistosomiasis, with minimal toxicity to animals, and is rapidly absorbed in the digestive tract after oral administration. 

Praziquantel Raw Materials is a broad-spectrum antiparasitic drug that is effective against Schistosoma japonicum, Schistosoma mansoni and Schistosoma aegypti, Schistosoma huaji, Schistosoma pulmonarum, Schistosoma gingerserae, cestodes, and Cysticercus, and is also effective against helminths.Praziquantel Raw Materials is a strong anthelmintic, especially against cestodes.

Praziquantel Raw Materials has a strong killing effect on tapeworms in particular, and is one of the most productive drugs for schistosomiasis at present.

Uses and functions of Praziquantel / Biltricide Powder.

Praziquantel is a broad-spectrum antiparasitic drug, effective anthelmintic against Schistosoma japonicum, Schistosoma mansoni and Schistosoma aegypti, Schistosoma oryzae, Schistosoma pulmonarum, Schistosoma gingersnake, cestodes and cysticerci.

Especially, it has strong killing effect on tapeworms, and it is one of the most productive schistosomiasis drugs available.

Pharmacological Effects of Praziquantel / Biltricide Powder.

Praziquantel has a significant killing effect on adult schistosomes. Its insecticidal mechanism, from the molecular level, is praziquantel rapidly disrupts the Ca2+ balance in the body of the worm, on the one hand, leading to excitation of the worm's activity, muscle contracture, so that the schistosomes parasitized in the portal system can not be adsorbed on the blood vessel wall and carried by the blood flow into the liver (liver migration), and then damaged; Secondly, it leads to the combination of schistosomes in the body of the worm, which is the most effective way to kill the adult schistosomes.

Secondly, it leads to the damage of the syncytiotrophoblast cortex of schistosomes, which not only affects the absorption, excretion and secretion functions of the worms and leads to the disorders of glucose metabolism and enzyme system, but also exposes the antigenic determinants of the worms on the surface of the body, which can be recognized by the immune system of the hosts, and attracts a large number of inflammatory cells, such as neutrophils, eosinophils, and macrophages to gather around the worms to exert attacks.

Praziquantel is a broad-spectrum antiparasitic drug, effective Anthelmintic against Schistosoma japonicum, Schistosoma mansoni and Schistosoma aegypti, Schistosoma oryzae, Schistosoma pulmonarum, Schistosoma gingersnakei, cestodes, and cysticerci.

Especially, it has strong killing effect on tapeworms, and it is the best one among the current schistosomiasis drugs.

Production method of Praziquantel / Biltricide Powder.

There are many synthetic routes in industrial production: isoquinoline route, piperazine route and phenethylamine route, among which the quinoline route is better. From the addition of isoquinoline with benzoyl chloride and potassium cyanide, catalytic hydrogenation, rearrangement of 1-benzoylamino-methyl-1,2,3,4-tetrahydroisoquinoline, and then chloroacetylation, cyclization, hydrolysis under pressure, cyclohexanoylated to obtain praziquantel.

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