Bleomycin Sulfate CAS 9041-93-4 Raw Materials Powder

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Bleomycin Sulfate Powder  Usage and Synthesis.

Bleomycin Sulfate Powder (NSC125066) is a glycopeptide antibiotic and an anti-cancer agent for squamous cell carcinoma (SCC). It is a broad-spectrum antitumor agent. It is effective against squamous carcinomas, including those of the head and neck, skin, esophagus, lung, cervix, penis, and thyroid, as well as malignant lymphomas.Bleomycin Sulfate Raw Materials is also effective against brain tumors, malignant melanoma, and fibrosarcoma.Bleomycin Sulfate CAS 9041-93-4 contains a number of similarly characterized It is a weakly basic substance. It is soluble in water, methanol, slightly soluble in ethanol, almost insoluble in acetone, ethyl acetate, butyl acetate and ether. It is blue-green when it contains copper ion, and white powder after removing copper ion.

Application/Function of Bleomycin Sulfate Powder.

Bleomycin Sulfate Powder is a broad-spectrum antitumor agent. It is effective against squamous carcinomas, including those of the head and neck, skin, esophagus, lung, cervix, penis and thyroid, as well as malignant lymphomas. It is also effective against brain tumors, malignant melanoma and fibrosarcoma.

As a selective agent the recommended concentration is 10-100 mcg/mL. Bleomycin Sulfate is used as a selective agent for transformed cells, especially for the transformation of vegetative cells. The recommended concentration is 10-100 g/mL. It can also be used to induce apoptosis in lung fibrotic epithelial cells.

Production Method of Bleomycin Sulfate Powder

This product is extracted from Streptomyces rotundus (Str. Verticillus), the same antibiotic isolated in our country from Actinomyces sp. 72. The production process is three-stage fermentation, the medium is starch, glucose, soybean cake powder, yeast powder, corn pulp, sodium chloride, zinc sulfate, copper sulfate, potassium dihydrogen phosphate, the fermentation process every 8 hours to replenish the glucose mother liquor, control the fermentation solution residual sugar at about 1%, to be pH back up to start every 8h to replenish corn pulp, each replenishment amount is 0.5%, bleomycin fermentation in the middle does not produce foam, so do not need to add Froth elimination oil is not needed. 

The refining process uses the property that bleomycin can dissociate into cations in aqueous solution, separates with weakly acidic acrylic acid cation exchange resin, extracts the limit, uses phenylhydrazine sulfur carbonyl azobenzene as chelating agent in methanol solution or hydrogen sulfide to remove copper ions, repeatedly precipitates with acetone, filters after refining, and vacuum dries to get the finished product.

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