Thiamine chloride raw Materials Powder

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Thiamine chloride Powder Usage and Synthesis.

Vitamin B1 is one of the B vitamins, mainly used for the prevention and treatment of vitamin B1 deficiency and its caused by pediculosis or Wernickes' encephalopathy, also used for peripheral neuritis, myocarditis, dyspepsia, congestive heart failure and other adjuvant therapy; used for vitamin B1 supplementation: including burns, fever, long term chronic infections patients; malabsorption syndrome with liver and biliary system disorders (e.g. alcoholism with Cirrhosis), small intestinal diseases (such as celiac disease, persistent diarrhea, etc.), gastrectomy, hyperthyroidism and hemodialysis patients; malnutrition caused by prolonged parenteral nutrition or insufficient intake, heavy laborers, as well as pregnant women, lactating women.

Uses of Thiamine chloride.

Vitamin B1 maintains normal nerve and myocardial function. There is evidence that patients with congestive heart failure often have vitamin B1 deficiencies as a result of diuretic use.

A small, double-blind study found that intravenous vitamin B1 given to patients with congestive heart failure improved their cardiac function. Similar results were found in another earlier study without a control group.

Vitamin B1 can also be supplemented Vitamin B1 will be helpful for people who drink alcohol, have Crohn's disease, are anorexic, or have multiple sclerosis, and it can be used as part of systemic nutritional support.

Vitamin B1 can also be used as a treatment for epilepsy, ulcer pain and muscle fiber pain, but of course this needs to be confirmed with further studies.

Pharmacological effect of Thiamine chloride.

In vivo, it combines with ATP to form pyrophosphate of B1, which plays an important role in the decarboxylation reaction of α-keto acid in sugar metabolism, changing pyruvate to acetate, and through the tricarboxylic acid cycle, forming an important connection between glycolysis and oxidative metabolism, promoting carbohydrate metabolism.

When the lack of vitamin B1, pyruvate decarboxylation oxidation is blocked, resulting in the accumulation of intracellular pyruvate, lactate, so that the small arteries dilate, diastolic blood pressure decreases, myocardial metabolism is dysfunctional, and in severe cases, there are circulatory disorders that lead to cardiac insufficiency, generalized edema and so on.

Impaired glucose metabolism, reducing the body's energy supply, so that the normal nerve involvement, sensory abnormalities, vision loss, muscle aches and pains and other symptoms of peripheral neuritis. In addition, vitamin B1 can inhibit the vitality of cholinesterase, and when it is lacking, cholinesterase activity increases, acetylcholine hydrolysis is accelerated, resulting in nerve impulse conduction disorders, affecting gastrointestinal and cardiac function.

Mainly absorbed through the gastrointestinal tract, distributed in all tissues T1/2 for 0.35 hours, metabolized in the liver, excreted through the kidney, normal people daily absorption of vitamin B1 is 5 to 15mg.

Product Method of Bulk Thiamine chloride Powder.

Thiamine hydrochloride is usually obtained by condensation, hydrolysis, neutralization, oxidation and acidification of an excess of acetamidine hydrochloride with α-dimethoxy β-methoxypropionitrile.

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