Feed additive Bulk Sulfadiazine Powder

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Sulfadiazine Powder Usage and Synthesis.

Sulfadiazine has an inhibitory effect on sensitive bacteria such as haemolytic streptococci, staphylococci, meningococci, pneumococci, gonococci, Escherichia coli, dysentery bacilli as well as microorganisms such as Chlamydia trachomatis, Actinobacillus, Plasmodium, Nucella asteroides and Toxoplasma gondii.

The advantages of sulfadiazine are high effective concentration in blood, low serum protein binding rate, the drug is easy to penetrate into the cerebrospinal fluid, the drug of choice for the treatment of epidemic meningitis, but in recent years there has been an increase in the number of resistant strains of meningococcus to sulfadiazine and other sulfonamides (20% of the domestic report, 33% of the foreign report of the resistance to this product).

Those who are resistant to this product can be treated with penicillin. The disadvantage of sulfadiazine is that it is easy to precipitate crystals in the urinary tract, so it is necessary to take sodium bicarbonate with it. In recent years, studies have shown that its half-life is 17 hours, so it can be a medium-acting sulfonamides, can be given twice a day.

However, it is still used as short-acting. Sulfadiazine is commonly used in the treatment of epidemic cerebrospinal meningitis, upper respiratory tract infections, epidemic meningitis, otitis media, carbuncle boils, puerperal fever, bubonic plague, local soft tissue or systemic infections, urinary tract infections, and acute bacillary dysentery, and can also be used for respiratory infections, intestinal infections, typhoid fever and so on.

Uses and functions of Sulfadiazine.

It is an excellent variety of sulphonamides with stronger antibacterial effect, better efficacy, faster absorption, slower excretion and higher effective concentration in blood. It is clinically used for the treatment of upper respiratory tract infections. Epidemic meningitis, otitis media, boils and carbuncles, puerperal fever, urinary tract infection and acute bacillary dysentery.

Sulfonamides for the treatment of infections caused by haemolytic streptococci, pneumococci, meningococci, diplococci of gonorrhoea, Escherichia coli.

Pharmacological Effect of Chondroitin Sulfate.

Sulfadiazine is an intermediate-acting sulfonamide with antimicrobial activity against non-enzyme-producing Aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Enterobacteriaceae such as Klebsiella spp, Salmonella spp, Shigella spp, Gonococcus spp, meningococcus, Haemophilus influenzae, and also has antimicrobial activity against Chlamydia trachomatis, Nucella satellitans, Plasmodium spp, and Toxoplasma gondii in vitro.

Sulfadiazine has the same antibacterial activity as sulfamethazine. However, in recent years, bacterial resistance to this product has increased, especially Streptococcus spp. and Neisseria spp. as well as Enterobacteriaceae. Sulfonamides are broad-spectrum bacteriostatic agents.

Sulfadiazine is structurally similar to p-aminobenzoic acid (PABA), can compete with PABA in the bacterial body of dihydrofolate synthase, thus preventing PABA as a raw material for the synthesis of bacterial folic acid, reducing the amount of metabolically active tetrahydrofolate, which is the synthesis of bacterial purine, thymine nucleoside and deoxyribonucleic acid (DNA) of the necessary substances, so inhibiting the growth and reproduction of bacteria. growth and reproduction.

Product Method of  Bulk Sulfadiazine Powder.

It is obtained by ammonia oxidation, condensation, alcohol precipitation and refining with propargyl alcohol as raw material.

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