Guanidine Hydrochloride Raw Materials powder

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Guanidine Hydrochloride powder Usage and Synthesis.

Guanidine hydrochloride has a certain antibacterial effect on Streptococcus pneumoniae, hemolytic streptococcus, Chlorococcus vermilia and some staphylococcus, Bacillus percosus, Bacillus anthracis, Bacillus pestis, Bacillus diphtheria, Bacillus tetanus, Brucella, Haemophilus influenzae, Campylobacter, Vibrio cholerae, and also has an inhibitory effect on Rickettsiae, mycoplasma, Chlamydia, spirochaetes, and some protozoa. Enterobacteriaceae bacteria such as Escherichia coli, Klebsiella, Salmonella, Shigella and so on most of the drug resistance. The effect of this product on gram-positive bacteria is better than that of Gram-positive bacteria, but enterococcus is resistant to it.

Uses of Guanidine Hydrochloride powder.

Guanidine hydrochloride is a strong ionic protein denaturant. As a protein denaturant, it can dissolve some insoluble or denatured proteins, such as endosomes; It can also be used for the initial folding of active proteins or enzymes; As a strong denaturant in the experiment of extracting total RNA from cells. Because of its biological destructive properties, buffers containing guanidine hydrochloride or guanidine thiocyanate are often called dissociated buffers.

It can be used as intermediates in medicine, pesticides, dyes and other organic synthesis. It can be used to synthesize 2-aminopyrimidine, 2-amino-6-methylpyrimidine, 2-amino-4, 6-dimethylpyrimidine, and is an intermediate in the manufacture of sulfadiazine, sulfadimethyrimidine, sulfadimethyrimidine and other sulfonamide drugs. Guanidine hydrochloride (or guanidine nitrate) reacts with ethyl cyanoacetate to form 2, 4-diamino-6-hydroxypyrimidine, which is used to synthesize folic acid, an antianemia drug. It can also be used as an antistatic agent for synthetic fibers.

It is mainly used as an intermediate of drugs, and is an important raw material for the manufacture of sulfadiazine, sulfadimethazine, sulfadimethazine and folate.

Preparation of Guanidine Hydrochloride powder.

The preparation method of guanidine hydrochloride has the following process flow:

a, melting, the weight ratio of 1∶1.27 dicyandiamide and ammonium chloride into the reactor, melting reaction at 170 ~ 230℃, to obtain guanidine hydrochloride crude product;

b, dissolve, at room temperature, dissolve guanidine hydrochloride in water at a ratio of 1 to 1, and add ammonium salt alkali to the solution according to the content of ammonium salt in guanidine hydrochloride;

c, filtration, the raw materials and reaction by-products are removed by filtration method;

d, dehydration, the filtered mother liquor at high temperature dehydration;

e, crystallization, supersaturated solution cooling, concentrated crystallization, to obtain high-purity guanidine hydrochloride.

f, the guanidine hydrochloride after step e is added into the dicyandiamide into the reactor, the melting reaction is carried out at 170 ~ 230℃ for 3 ~ 4h, and then through steps b, c, d, e, to obtain higher purity guanidine hydrochloride, and this step can be repeated several times according to needs.

g. The guanidine hydrochloride after step e is then passed through steps b, c, d and e, where the ratio of step b to water is 1.5∶1 to obtain higher purity guanidine hydrochloride, and this step can be repeated several times as needed.

Product method of Bulk Guanidine Hydrochloride powder.

Using dicyandiamide and ammonium salt (ammonium chloride) as raw materials, guanidine hydrochloride was melted at 170-230℃, and the finished product was obtained by refining.

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